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Afternoon vs Morning Exercise for Prediabetes (TIMED Trial)

N/A

Recruiting

Led By Denis P. Blondin, PhD

Research Sponsored by Université de Sherbrooke

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Pre-diabetes: Fasting plasma glucose: 6.1 to 6.9 mmol/L or 2-hour plasma glucose post 75g OGTT: 7.8 to 11.0 mmol/L and HbA1c: 6.0 to 6.4% or Insulin resistant: glucose clearance rate ≤ 360 ml/kg/min as determined using the Oral Glucose Insulin Sensitivity Index at Time 120 min.

Be older than 18 years old

Must not have

Prior history or current fasting plasma cholesterol level > 7 mmol/l or fasting TG > 6 mmol/l

Overt cardiovascular disease as assessed by medical history, physical exam, and abnormal ECG

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured continuously 2-3 days before and 2-3 days after first and final exercise session, after 12-week exercise intervention.

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether afternoon exercise is more effective than morning exercise in improving 24-hour blood glucose levels in men with prediabetes.

Who is the study for?

This trial is for men and women with prediabetes, defined by specific blood sugar levels or insulin resistance. Participants must have a BMI over 25, be able to follow the study protocol, and provide informed consent. Exclusions include recent scans, smoking, heavy drinking, certain medical conditions like uncontrolled thyroid disorders or heart disease, and use of medications affecting metabolism.

What is being tested?

The trial tests whether exercising at different times (morning vs late afternoon) affects blood sugar control in people with prediabetes. It aims to see if timing exercise can improve how the body uses insulin and manages dietary fats in muscles and fat tissue.

What are the potential side effects?

High-intensity interval training generally has few side effects but may include muscle soreness, fatigue after workouts, increased risk of injury if not performed correctly, and possible exacerbation of underlying health issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have pre-diabetes or insulin resistance based on my blood sugar tests.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My cholesterol or triglycerides levels have been high.

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I have heart disease confirmed by my doctor and tests.

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My blood pressure is not higher than 180/110 mm Hg.

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I have a history of heart issues or take medication that affects my heart's rhythm.

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I have had serious stomach or intestine problems.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured continuously 2-3 days before and 2-3 days after first and final exercise session, after 12-week exercise intervention.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured continuously 2-3 days before and 2-3 days after first and final exercise session, after 12-week exercise intervention.

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured continuously 2-3 days before and 2-3 days after first and final exercise session, after 12-week exercise intervention. for reporting.