Mutamycin

Glaucoma, Mesothelioma, Breast Cancer + 7 more
Treatment
6 FDA approvals
20 Active Studies for Mutamycin

What is Mutamycin

MitomycinThe Generic name of this drug
Treatment SummaryMitomycin is an antibiotic used to treat cancer. It was first discovered in the 1950s by Japanese microbiologists and works by inhibiting the replication of DNA. It is an alkylating agent, which means it creates a cross-link between the two strands of the DNA double helix. Few other antibiotics have this same type of effect, making it a rare and unique treatment option. Mitomycin has been approved for use in a variety of cancers, as well as to reduce eye pressure during certain surgeries.
Mutamycinis the brand name
image of different drug pills on a surface
Mutamycin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mutamycin
Mitomycin
1981
46

Approved as Treatment by the FDA

Mitomycin, also called Mutamycin, is approved by the FDA for 6 uses such as Adenocarcinoma of the Stomach and ab externo surgery Glaucoma .
Adenocarcinoma of the Stomach
Used to treat Adenocarcinoma of the Stomach in combination with null
ab externo surgery Glaucoma
Adenocarcinomas of the Pancreas
Used to treat Adenocarcinomas of the Pancreas in combination with null
Gastric Adenocarcinoma
Used to treat Adenocarcinoma of the Stomach in combination with null
Pancreatic Adenocarcinoma
Used to treat Adenocarcinomas of the Pancreas in combination with null
Glaucoma

Effectiveness

How Mutamycin Affects PatientsMitomycin is an older chemotherapy drug that has been used for many years. It is an antibiotic and can help fight tumors. Mitomycin works by blocking DNA, RNA, and protein synthesis. It also can prevent cells such as B cells, T cells, and macrophages from growing, and can stop certain substances like interferon gamma, TNFa, and IL-2 from being released.
How Mutamycin works in the bodyMitomycin is activated in the body to a form that binds to DNA and prevents it from functioning properly. This binding causes areas of the DNA to link together, preventing it from replicating. Mitomycin works in all phases of the cell cycle and doesn't discriminate against any.

When to interrupt dosage

The amount of Mutamycin is contingent upon the diagnosed condition, including Gastric Adenocarcinoma, Cervical Cancer and Glaucoma. The dosage can also be found in the table below, contingent upon the method of delivery.
Condition
Dosage
Administration
Head and Neck Neoplasms
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Glaucoma
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Mesothelioma
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Breast Cancer
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Gastric Adenocarcinoma
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Non-Small Cell Lung Cancer
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Anus Neoplasms
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Bladder Cancer
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Pancreatic Adenocarcinoma
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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low-grade Upper Tract Urothelial Cancer (LG-UTUC)
, 2.0 mg/mL, 0.5 mg/mL, 4.0 mg/mL, 20.0 mg, 5.0 mg, 0.2 mg/mL, 40.0 mg
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Warnings

Mutamycin Contraindications
Condition
Risk Level
Notes
increase in bleeding tendency
Do Not Combine
Low Platelet Count
Do Not Combine
Blood Coagulation Disorders
Do Not Combine
There are 20 known major drug interactions with Mutamycin.
Common Mutamycin Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Mitomycin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Mitomycin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Mitomycin is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Mitomycin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Mitomycin is combined with Acteoside.
Mutamycin Toxicity & Overdose RiskThe toxic dose of the drug in mice has been found to be 23mg/kg and 30mg/kg in rats. Those who overdose on the drug may experience nausea and vomiting.

Mutamycin Novel Uses: Which Conditions Have a Clinical Trial Featuring Mutamycin?

There are presently 1386 investigations in progress, assessing the potential of Mutamycin in managing Cervical Cancer, Bladder Cancer and Pancreatic Adenocarcinoma.
Condition
Clinical Trials
Trial Phases
Bladder Cancer
103 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Gastric Adenocarcinoma
28 Actively Recruiting
Phase 4, Phase 2, Phase 1, Phase 3
Glaucoma
0 Actively Recruiting
Breast Cancer
25 Actively Recruiting
Phase 2, Phase 1, Not Applicable
Mesothelioma
0 Actively Recruiting
low-grade Upper Tract Urothelial Cancer (LG-UTUC)
0 Actively Recruiting
Anus Neoplasms
15 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1
Pancreatic Adenocarcinoma
65 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Non-Small Cell Lung Cancer
338 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4, Early Phase 1
Head and Neck Neoplasms
5 Actively Recruiting
Not Applicable, Phase 1

Mutamycin Reviews: What are patients saying about Mutamycin?

3Patient Review
9/18/2014
Mutamycin for Cancer of the Bladder
The doctor administered this treatment via a catheter, which was uncomfortable but not painful. A few days after each treatment, I experienced a low-grade fever--this happened after every single treatment. I received six treatments in total, on a weekly basis. It's too soon to tell if the treatment was effective or not.
3Patient Review
2/28/2020
Mutamycin for Cancer of the Bladder
The surgery to remove the tumor was successful, and now I've started chemo. So far it's been tough because of fatigue, but it's only my third treatment.
3Patient Review
9/18/2014
Mutamycin for Cancer of the Bladder
The doctor administering this treatment was via a catheter, which was uncomfortable but not painful. A few days after each treatment, I experienced a low-grade fever similar to the flu. This happened after every weekly treatment. It's too soon to tell if the treatments were effective.
3Patient Review
2/28/2020
Mutamycin for Cancer of the Bladder
The surgery to remove the tumor went well, and chemo has been manageable so far. The fatigue has been the worst part, but I'm almost done with treatment.
1.3Patient Review
3/11/2010
Mutamycin for Cancer of the Bladder
Unfortunately, this medication caused a number of issues for me, including a skin rash, fatigue, and irritation/itching around my bladder and urethra.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about mutamycin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How do you give a Mitomycin injection?

"In cytostatic monochemotherapy mitomycin is usually given as an intravenous injection all at once. The recommended dosage is 10 - 20 mg/m2 of body surface every 6 - 8 weeks, 8 - 12 mg/m2 of body surface every 3 - 4 weeks, or 5-10 mg/m2 of body surface every 1-6 weeks depending on which therapeutic scheme is used."

Answered by AI

When is Mitomycin used for bladder cancer?

"The chemotherapy drug Mitomycin is used to kill any cancer cells that may have remained in your bladder after surgery. The drug remains in your bladder for one to two hours and is then drained out through the urinary catheter, or leaves your bladder when you pass urine."

Answered by AI

What is Mitomycin used for?

"Mitomycin is an antibiotic that is only used in cancer chemotherapy. It slows or stops the growth of cancer cells."

Answered by AI

Is Mitomycin a chemotherapy?

"Mitomycin C is a chemotherapy drug that treats various types of cancer."

Answered by AI

Clinical Trials for Mutamycin

Have you considered Mutamycin clinical trials? We made a collection of clinical trials featuring Mutamycin, we think they might fit your search criteria.
Have you considered Mutamycin clinical trials? We made a collection of clinical trials featuring Mutamycin, we think they might fit your search criteria.
Have you considered Mutamycin clinical trials? We made a collection of clinical trials featuring Mutamycin, we think they might fit your search criteria.
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