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Behavioral Effects for Opioid Use Disorder (BED(In)(44) Trial)

Phase < 1

Recruiting

Research Sponsored by Joshua A. Lile, Ph.D.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Between the ages of 18-50 years

Be between 18 and 65 years old

Must not have

Vision or hearing problems that would preclude completion of experimental tasks

Poor venous access

Timeline

Screening 3 weeks

Treatment Varies

Follow Up tasks will take approximately 45-60 minutes to complete. participants will complete 5 sessions in which a choice task will be administered.

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study how the brain makes decisions in people with opioid addiction using brain scans and computer tasks.

Who is the study for?

This trial is for individuals aged 18-50 with moderate to severe opioid use disorder, who have used opioids like heroin or fentanyl recently. They must be physically dependent on these drugs, able to speak and read English, and not pregnant if female (effective birth control required). Participants should also be generally healthy with normal oxygen levels.

What is being tested?

The study aims to understand decision-making in people with opioid addiction by using tasks that involve choosing between money or drug-related cues while undergoing withdrawal. Brain activity will be monitored through fMRI scans during these tasks.

What are the potential side effects?

Since this trial involves behavioral assessments rather than medication trials, traditional side effects are not a concern. However, participants may experience discomfort related to withdrawal symptoms during the study.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 50 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I do not have vision or hearing issues that would stop me from completing study tasks.

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I have difficult veins for drawing blood or giving IV treatments.

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I do not have any major health or mental issues that would stop me from following study rules.

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I am seeking treatment for substance use disorder or currently use buprenorphine or methadone.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ tasks will take approximately 45-60 minutes to complete. participants will complete 5 sessions in which a choice task will be administered.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~tasks will take approximately 45-60 minutes to complete. participants will complete 5 sessions in which a choice task will be administered.

This trial's timeline: 3 weeks for screening, Varies for treatment, and tasks will take approximately 45-60 minutes to complete. participants will complete 5 sessions in which a choice task will be administered. for reporting.