Norethindrone Acetate

Endometriosis, Low Testosterone, Osteoporosis + 16 more
Treatment
20 Active Studies for Norethindrone Acetate

What is Norethindrone Acetate

NorethisteroneThe Generic name of this drug
Treatment SummaryNorethisterone, also known as norethindrone, is a synthetic hormone used to imitate the effects of progesterone. It is more powerful than other progestins like levonorgestrel and norethynodrel, and is used in contraception and hormone replacement therapies. It was developed in 1951 in Mexico City to treat irregular menstruation and endometriosis, and was approved for use as an oral contraceptive in 1962.
Neconis the brand name
image of different drug pills on a surface
Norethindrone Acetate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347

Effectiveness

How Norethindrone Acetate Affects PatientsNorethisterone is a type of medicine taken by mouth to either prevent pregnancy or treat other hormone-related conditions such as menopause and endometriosis. It works in a similar way to the hormone progesterone, but is much more powerful. It affects the pelvic area, cervical and endometrial function, and stops hormones from maturing and releasing eggs. Taking norethisterone has been linked to a slightly higher risk of breast cancer, so it is important for patients to be aware of this and to regularly check their breasts for any changes.
How Norethindrone Acetate works in the bodyNorethisterone works by binding to progesterone receptors in the reproductive tract, breast, pituitary, hypothalamus, skeletal tissue, and central nervous system. It thickens the cervical mucus to block sperm from entering, makes the endometrium inhospitable for implantation, and suppresses hormones that cause follicular development and ovulation. When combined with estrogen in postmenopausal women, norethisterone helps protect against endometrial hyperplasia, which can lead to cancer. It has low affinity for other steroid receptors such as the androgen receptor and glucocorticoid receptor, but is

When to interrupt dosage

The recommended measure of Norethindrone Acetate is contingent upon the diagnosed condition, including Atrophic, Fracture and Hormone Replacement Therapy. The dosage fluctuates depending on the technique of administration (e.g. Oral or Tablet) as indicated in the following table.
Condition
Dosage
Administration
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis, Postmenopausal
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Primary Ovarian Insufficiency
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Warnings

Norethindrone Acetate Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
Liver Diseases
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
There are 20 known major drug interactions with Norethindrone Acetate.
Common Norethindrone Acetate Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Norethindrone Acetate Toxicity & Overdose RiskThe toxic dose of oral contraceptives in mice is 6g/kg, and in human women is 42mg/kg. There are no known serious side effects from taking too much of this medication. Common symptoms of overdosing on oral contraceptives include nausea and vomiting.
image of a doctor in a lab doing drug, clinical research

Norethindrone Acetate Novel Uses: Which Conditions Have a Clinical Trial Featuring Norethindrone Acetate?

160 active clinical trials are being conducted to evaluate the effectiveness of Norethindrone Acetate in providing Birth Control, countering Atrophic changes and Low Testosterone levels.
Condition
Clinical Trials
Trial Phases
Atrophic
4 Actively Recruiting
Phase 4, Not Applicable
Endometriosis
34 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1
Osteoporosis
32 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Birth Control
28 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Low Testosterone
6 Actively Recruiting
Phase 4, Phase 2, Phase 1
Endometriosis
3 Actively Recruiting
Phase 4, Not Applicable
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Hot flashes
13 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Early Phase 1
Osteoporosis, Postmenopausal
0 Actively Recruiting
Estrogen Deprivation Symptoms
0 Actively Recruiting
female castration
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
hypoestrogenism
1 Actively Recruiting
Phase 4
Fracture
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Primary Ovarian Insufficiency
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Menopause
0 Actively Recruiting

Norethindrone Acetate Reviews: What are patients saying about Norethindrone Acetate?

5Patient Review
8/10/2012
Norethindrone Acetate for Absence of Menstrual Periods in Woman Who Has Had Them
This medication is exactly as my doctor said it would be. I take it for the first 10 days of each month, and then my period starts about 3 days after I stop the pills. The side effects are tiredness, hunger, and a small amount of swelling in my feet; however, these are manageable considering the price and effectiveness of the medication.
5Patient Review
9/15/2016
Norethindrone Acetate for Abnormal Uterine Bleeding caused by Imbalance of Hormones
It took a little while to see results, but this treatment has been great for me. I haven't had any negative side effects in the two years that I've been taking it.
5Patient Review
5/14/2014
Norethindrone Acetate for Endometriosis
I was in a lot of pain after my hysterectomy, and this medication really helped. Within days I felt relief. It's the only thing I take now for endometriosis, and it's worth it.
4.7Patient Review
5/24/2015
Norethindrone Acetate for Abnormal Uterine Bleeding caused by Imbalance of Hormones
I had tried all natural remedies because I'm not fond of taking medications due to my sensitive system.I was flooding with huge clots for 32 days straight and after the second day of taking a total of 8 pills, the bleeding stopped. It has been over 2 weeks,gained 2 pounds but to me thats better than getting the hysterectomy my gyno recommended due to a fibroid.Hoping I can stay on this pill for a long time instead of surgery.
4.7Patient Review
3/20/2016
Norethindrone Acetate for Abnormal Uterine Bleeding caused by Imbalance of Hormones
This treatment has been effective in stopping my irregular bleeding, but I have experienced fatigue as a side effect.
4.3Patient Review
9/25/2013
Norethindrone Acetate for Abnormal Uterine Bleeding caused by Imbalance of Hormones
I took this drug for over a year to help with premenopausal/menopause constant bleeding. It eventually stopped the non-stop bleeding after two months, which was great. However, it caused some major disruptions to my sleeping patterns and severe mood swings and depression.
3.7Patient Review
10/31/2015
Norethindrone Acetate for Endometriosis
I saw a lot of success in the first two months of taking this medication, but unfortunately the pain has started to come back. I'm now resorting to daily ibuprofen again, which doesn't seem to be helping as much as it used to. I'm not sure what my next step should be, as Lupron sounds like a terrible option.
2.7Patient Review
3/5/2015
Norethindrone Acetate for Abnormal Uterine Bleeding caused by Imbalance of Hormones
While this medication did help to lessen the amount of pain I experience during my period, it also caused me to have more large and painful clots.
1Patient Review
1/26/2016
Norethindrone Acetate for Endometriosis
I began this medication on 1/6/16 and have experienced hot flashes, night sweats, a rash on my back, mood swings, and weight gain (15lbs). I see no change in my pain levels. Overall, I would not recommend taking Norethindrone or the Lupron Depot shot.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about norethindrone acetate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Will norethindrone acetate stop my period?

"Norethindrone reduces the activity of estrogen receptors on the endometrium, which prevents endometrial cell growth, enhances glandular secretion, and helps maintain the endometrium. Therefore, norethindrone can help prevent the endometrium from breaking down and bleeding."

Answered by AI

Is norethindrone acetate a birth control?

"The products NORETHINDRONE ACETATE and ETHINYL ESTRADIOL are an oral contraceptive that prevent ovulation and pregnancy by combining two types of female hormones, an estrogen and a progestin."

Answered by AI

What is norethindrone acetate used for?

"NORETHINDRONE ACETATE is a female hormone used to treat endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Secondary amenorrhea refers to when a woman stops getting menstrual periods due to low levels of certain female hormones."

Answered by AI

What are the side effects to norethindrone?

"If you experience any of the following symptoms, you may be pregnant: irregular vaginal bleeding or spotting, changes in your menstrual flow, larger or more tender breasts, nausea, vomiting, bloating, weight changes, difficulty falling asleep or staying asleep."

Answered by AI

Clinical Trials for Norethindrone Acetate

Have you considered Norethindrone Acetate clinical trials? We made a collection of clinical trials featuring Norethindrone Acetate, we think they might fit your search criteria.
Have you considered Norethindrone Acetate clinical trials? We made a collection of clinical trials featuring Norethindrone Acetate, we think they might fit your search criteria.
Have you considered Norethindrone Acetate clinical trials? We made a collection of clinical trials featuring Norethindrone Acetate, we think they might fit your search criteria.
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