Ketamine Infusion for Neuralgia

Recruiting in Palo Alto (17 mi)

Overseen byAlexander Shin, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Mayo Clinic

No Placebo Group

Prior Safety Data

Approved in 3 Jurisdictions

Trial Summary

What is the purpose of this trial?

This trial is testing if giving ketamine can help reduce severe nerve pain in patients with brachial plexus injuries. Ketamine works by blocking pain signals to the brain. The study aims to see if this reduces the need for other pain medications. Ketamine has been reported to enhance the pain-relieving effects of local anesthetics and is used primarily for patients who are tolerant to opioids and those with severe acute pain.

Eligibility Criteria

This trial is for adults with severe nerve pain due to traumatic brachial plexus injuries, confirmed by CT myelogram. Participants must experience specific types of neuropathic pain and score over 4/10 on a specialized pain questionnaire. They should be scheduled for surgery at Mayo Clinic. Excluded are those without pain, under 18, not needing surgery, or with conditions like liver disease or schizophrenia that make ketamine use risky.

Inclusion Criteria

I am scheduled for nerve surgery at Mayo Clinic due to pain from a severe arm injury.

I have nerve pain scoring over 4 on a specific pain questionnaire.

You have nerve damage in your spine as shown on a CT myelogram.

See 2 more

Exclusion Criteria

I do not have severe liver issues, heart disease, or uncontrolled schizophrenia.

I do not have pain after a severe shoulder nerve injury.

I am under 18 years old.

See 2 more

Treatment Details

Interventions

Ketamine Infusion (NMDA Receptor Antagonist)

Trial OverviewThe study tests whether ketamine given during surgery can help reduce the intense nerve pain associated with brachial plexus avulsion injuries. It measures patients' neuropathic pain levels before and after their operations to see if there's any improvement.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: Ketamine Infusion GroupExperimental Treatment1 Intervention

Subjects will receive ketamine infusion during their planned surgery and postoperatively.

Group II: Standard of Care GroupActive Control1 Intervention

Subjects will receive general anesthesia as standard of care during their planned surgery

Ketamine Infusion is already approved in United States, European Union, Canada for the following indications:

🇺🇸 Approved in United States as Ketalar for: