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What is Probenecid
ProbenecidThe Generic name of this drug
Treatment SummaryProbenecid is a drug used to reduce the amount of uric acid in the body. It works by blocking the excretion of uric acid in the kidneys, and can also be used to treat patients with kidney problems. Additionally, it can be taken to reduce the amount of other drugs that are removed from the body by the kidneys.
Probenecidis the brand name
Probenecid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Probenecid
Probenecid
1976
20
Approved as Treatment by the FDA
Probenecid, otherwise known as Probenecid, is approved by the FDA for 7 uses like Arthritis, Gouty and Hyperuricemia .Arthritis, Gouty
Hyperuricemia
Chronic Gouty Arthritis
Used to treat Chronic Gouty Arthritis in combination with Colchicine
frequent attacks of gout
Used to treat frequent attacks of gout in combination with Colchicine
Infection
Arthritis, Gouty
Used to treat Chronic Gouty Arthritis in combination with Colchicine
Hyperuricemia
Effectiveness
How Probenecid Affects PatientsProbenecid is a drug that helps remove uric acid from the body, and is often prescribed along with colchicine to treat gout. It works by blocking the absorption of urate in the kidneys and increasing the amount of uric acid in urine. Additionally, it can stop certain acidic drugs (like penicillins and cephalosporins) from being filtered out of the body, which can help increase their levels in the bloodstream. This can be useful for treating gonorrhea, neurosyphilis, and PID (pelvic inflammatory disease).
How Probenecid works in the bodyProbenecid stops the kidneys from absorbing uric acid from the blood. This causes more uric acid to be excreted in the urine, reducing uric acid levels in the blood. The exact way it works is unknown, but it may be blocking proteins that help absorb uric acid or blocking access to the proteins that help absorb it.
When to interrupt dosage
The advised dosage of Probenecid is contingent upon the diagnosed disorder, for example Gouty Arthritis, Bacterial infection and recurrent gout assaults. The measure of dosage is subject to the technique of conveyance (e.g. Tablet, film coated or Oral) featured in the table beneath.Condition
Dosage
Administration
Arthritis, Gouty
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Hyperuricemia
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Infection
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Arthritis, Gouty
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Elevated Serum Uric Acid
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Gout
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
frequent attacks of gout
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Urinary Tract Infection (UTI)
, 500.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule; Tablet, Capsule; Tablet - Oral
Warnings
Probenecid ContraindicationsCondition
Risk Level
Notes
Urinary Bladder Calculi
Do Not Combine
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Common Probenecid Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Probenecid.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Probenecid.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Probenecid.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Probenecid.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Probenecid.
Probenecid Novel Uses: Which Conditions Have a Clinical Trial Featuring Probenecid?
48 active clinical trials are currently underway to assess the potential of Probenecid in managing Hyperuricemia, Arthritis, Gouty and Bacterial Infections.Condition
Clinical Trials
Trial Phases
Urinary Tract Infection (UTI)
9 Actively Recruiting
Phase 1, Phase 3, Phase 4, Not Applicable
Elevated Serum Uric Acid
0 Actively Recruiting
Hyperuricemia
5 Actively Recruiting
Phase 3, Phase 1, Phase 2
Arthritis, Gouty
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Arthritis, Gouty
0 Actively Recruiting
Infection
6 Actively Recruiting
Not Applicable, Phase 1
frequent attacks of gout
0 Actively Recruiting
Gout
0 Actively Recruiting
Probenecid Reviews: What are patients saying about Probenecid?
5Patient Review
1/2/2011 I was really struggling with gout pain. My doctor found high uric acid levels and put me on this medication. At first, the symptoms got worse but then they started to fade away. Now I'm only taking one pill a day and have had no more gout attacks. Plus, there are no side effects as long as you drink plenty of fluids.
5Patient Review
3/23/2017 My husband has been taking this medication, in combination with .06 colchicine, for close to two decades. He tried allopurinol, which made his gout worse and did not work. After being on allopurinol for months and experiencing increased frequency of attacks, his doctor put him on this medication. It's been great; the only time he has an attack is when he forgets to take his pill a few days in a row. Otherwise, it works great.
5Patient Review
4/2/2018 Probenecid really helped me with my gout attacks. I was attacking frequently, and it increased over time, but after starting this medication, I haven't had an issue in years.
5Patient Review
8/1/2010 Probenecid has been really effective for me in managing my gout.
5Patient Review
5/17/2011 I experienced no negative effects from this treatment.
Patient Q&A Section about probenecid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why probenecid is used with penicillin?
"Probenecid can be used with penicillin and penicillin derivatives to make them last longer in the bloodstream and increase serum concentrations. The typical dose for this is 1 g daily."
Answered by AI
What are the side effects of taking probenecid?
"You may experience a headache, dizziness, nausea, vomiting, loss of appetite, flushing, sore gums, increased urination, itching, rash, or hair loss."
Answered by AI
What type of drug is probenecid?
"Probenecid is a uricosuric drug, which means it helps to lower high levels of uric acid in the body by promoting the removal of uric acid by the kidneys. High levels of uric acid can lead to the formation of crystals in the joints, resulting in gout. Probenecid may also help to protect the kidneys."
Answered by AI