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Neuropeptide

Substance P for Type 1 Diabetes

Phase 1
Waitlist Available
Led By Etienne Sochett, MD
Research Sponsored by Vanilloid Genetics Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 and 6 months
Awards & highlights
No Placebo-Only Group

Summary

This trial tests if delivering a natural body chemical called substance P to a major artery can help people recently diagnosed with type 1 diabetes. The goal is to reduce inflammation and support the pancreas in managing blood sugar levels better.

Eligible Conditions
  • Type 1 Diabetes

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 and 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Stage A Safety: Side effects reported for entire cohort
Secondary study objectives
C-Peptide Levels (large cohort)
C-Peptide Levels (small cohort)
Other study objectives
sP Longevity

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Group I: Substance P - 5nmol/kgExperimental Treatment1 Intervention
Substance P 5nmol/kg intra-celiac artery, single treatment
Group II: Substance P - 45nmol/kgExperimental Treatment1 Intervention
Substance P 45nmol/kg intra-celiac artery, single treatment
Group III: Substance P - 1nmol/kgExperimental Treatment1 Intervention
Substance P 1nmol/kg intra-celiac artery, single treatment
Group IV: Substance P - 15nmol/kgExperimental Treatment1 Intervention
Substance P 15nmol/kg intra-celiac artery, single treatment
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Substance P
2021
N/A
~40

Find a Location

Who is running the clinical trial?

Vanilloid Genetics Inc.Lead Sponsor
Etienne Sochett, MDPrincipal InvestigatorHospital for Sick Children, Toronto Ontario
2 Previous Clinical Trials
26 Total Patients Enrolled
~1 spots leftby Nov 2025
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