Rifampin

Pruritus, Nasopharynx, Latent Tuberculosis + 4 more
Treatment
5 FDA approvals
2 Active Studies for Rifampin

What is Rifampin

RifampicinThe Generic name of this drug
Treatment SummaryRifampin is an antibiotic that is derived from Streptomyces mediterranei and is used to treat a wide range of bacterial infections. It works by stopping the bacteria from producing proteins necessary for their survival and multiplication, effectively killing them. Rifampin is effective against both intracellular and extracellular bacteria.
Rifadinis the brand name
image of different drug pills on a surface
Rifampin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rifadin
Rifampicin
1971
75

Approved as Treatment by the FDA

Rifampicin, otherwise known as Rifadin, is approved by the FDA for 5 uses which include late phase Tuberculosis and initial phase Tuberculosis .
late phase Tuberculosis
Used to treat late phase Tuberculosis in combination with Isoniazid
initial phase Tuberculosis
Used to treat initial phase Tuberculosis in combination with Isoniazid
Nasopharynx
Tuberculosis
Used to treat late phase Tuberculosis in combination with Isoniazid
Latent Tuberculosis
Used to treat initial phase Tuberculosis in combination with Isoniazid

Effectiveness

How Rifampin Affects PatientsRifampin is an antibiotic that stops bacteria from producing the proteins they need to survive. It is effective against most types of bacteria, including those that cause tuberculosis, and is usually taken by mouth. It is absorbed quickly and spread throughout the body, including the brain. Rifampin is processed in the liver and then removed from the body in bile. It can also be removed from the body in urine, although no dose adjustments are needed for patients with kidney problems. Because bacteria can become resistant to rifampin, it is only used to treat certain infections.
How Rifampin works in the bodyRifampin works by blocking the production of RNA in cells, which prevents them from functioning and leads to their death.

When to interrupt dosage

The prescribed quantity of Rifampin is contingent upon the diagnosed circumstance, for instance antibacterial therapy, Prosthetic Joint Infections and Nasopharynx. The dosage can be found in the table below, depending on the technique of delivery.
Condition
Dosage
Administration
Nasopharynx
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Latent Tuberculosis
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Tuberculosis
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
antibacterial therapy
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Staphylococcal Infections
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Prosthetic Joint Infections
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Pruritus
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral

Warnings

Rifampin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Rifampin.
Common Rifampin Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Rifampicin.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Rifampicin.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Rifampicin.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Rifampicin.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Rifampicin.
Rifampin Toxicity & Overdose RiskThe lethal dose of this drug for rats is 1570 mg/kg. Prolonged exposure could lead to nausea, vomiting, and loss of consciousness.
image of a doctor in a lab doing drug, clinical research

Rifampin Novel Uses: Which Conditions Have a Clinical Trial Featuring Rifampin?

Five current clinical trials are assessing the potential of Rifampin for managing late phase Tuberculosis, initial phase Tuberculosis and Pruritus.
Condition
Clinical Trials
Trial Phases
Tuberculosis
0 Actively Recruiting
Nasopharynx
0 Actively Recruiting
Latent Tuberculosis
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Staphylococcal Infections
0 Actively Recruiting
Prosthetic Joint Infections
2 Actively Recruiting
Phase 4, Not Applicable
Pruritus
0 Actively Recruiting

Patient Q&A Section about rifampin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is rifampin used to treat TB?

"Rifampin is a medicine used to treat latent tuberculosis infection (LTBI). It works by killing the tuberculosis bacteria before they wake up and make you sick. Because the bacteria are strong, it can take several months for the medicine to work. Make sure to take Rifampin as often and for as long as your healthcare provider tells you."

Answered by AI

What are the side effects of taking rifampin?

"Symptoms of indigestion may include: heartburn, abdominal pain, loss of appetite, nausea, vomiting, yellowing skin and eyes (jaundice), gas (flatulence), cramps."

Answered by AI

What is the most serious complication of rifampin?

"Liver problems have led to death in up to 1 out of 1000 people.

In some cases, people have had a severe reaction to rifampin, which can be deadly. Symptoms of this reaction may include fever, rash, or swollen glands, as well as problems with organs such as the liver, kidney, blood, heart, muscles, and joints, or lungs. If you have any questions, please speak to your doctor. In some instances, rifampin has been known to cause liver problems, which has resulted in death in up to one in every 1,000 people who take the medication."

Answered by AI

What type of antibiotic is rifampin?

"It is also effective against a number of other strains, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.

Rifampicin is an antibiotic used to treat bacterial infections, including tuberculosis, leprosy, and Legionnaires' disease. It is also effective against other strains, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis."

Answered by AI

Clinical Trials for Rifampin

Image of Dr, Adam Hart in Montréal, Canada.

Tourniquet Use for Prosthetic Joint Infections

18 - 85
All Sexes
Montréal, Canada
Tourniquet inflation during total knee arthroplasty (TKA) is commonly used to reduce bleeding in the surgical field; thereby facilitating exposure and cementation. However, reducing circulation to the leg may also reduce antibiotic distribution to the peri-incisional tissues. Once inflated, further parenteral addition of antibiotics is not likely to achieve peak concentration. Some studies propose techniques of regional prophylaxis with a tourniquet to achieve higher cefazolin tissue concentrations. To our knowledge, the effect of tourniquet application on antibiotic tissue concentrations during total knee arthroplasty has not been explored. Furthermore, the effect of time from dose to incision, participants weight, and length of surgery on local tissue concentrations of Ancef are poorly understood. Considering that infections remain the leading source of early reoperation and revision surgery, insight and optimization of local tissue antibiotics is of paramount interest.
Recruiting
Has No Placebo
Dr, Adam Hart (+1 Sites)Adam Hart, MD
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