Oral Antibiotics for Prosthetic Joint Infections

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen byNicholas Bedard, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University of Iowa

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.

Research Team

Nicholas Bedard, MD

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for adults needing a first-time hip or knee replacement who are at high risk of infection due to obesity, diabetes, smoking, kidney disease, autoimmune conditions, or nasal colonization with Staphylococcus bacteria. It's not for those allergic to the study antibiotics, unable to take oral meds, pregnant women, or patients planning other joint replacements soon.

Inclusion Criteria

I am scheduled for a first-time hip or knee replacement surgery.

I am at high risk for joint infections due to one or more health issues.

Exclusion Criteria

I am having or have had a hip or knee replacement redone.

I am allergic to certain antibiotics listed in the treatment plan.

Pregnant.

See 7 more

Treatment Details

Interventions

Cephalexin Oral Tablet (Anti-bacterial)
Doxycycline Hyclate (Anti-bacterial)

Trial OverviewThe trial tests if taking an antibiotic (Cephalexin, Doxycycline or Cefadroxil) for 7 days can prevent infections and wound issues after hip or knee replacement surgery in high-risk patients. Participants will receive one of these antibiotics as a preventative measure.

Participant Groups

2Treatment groups

Active Control

Group I: Additional Antibiotic GroupActive Control3 Interventions

Patients will receive an oral antibiotic to be started after completion of standard perioperative antibiotics following primary hip or knee arthroplasty. Oral antibiotic will either be a first-generation cephalosporin (Cefadroxil or Cephalexin) or Doxycycline based upon patient allergies, kidney function and result of nasal colonization testing for MRSA.

Group II: Control Group - No Additional AntibioticActive Control1 Intervention

Patients will receive standard perioperative antibiotics following primary hip or knee arthroplasty and no additional antibiotics.