Supprelin

Puberty, Precocious, Prostatic Neoplasms

Treatment

1 Active Study for Supprelin

Treatment for

Puberty, Precocious

What is Supprelin

HistrelinThe Generic name of this drug

Treatment SummaryHistrelin is a hormone-based medicine used to treat a variety of conditions. It is delivered in an implant that slowly releases medicine into the body to inhibit the release of hormones from the pituitary gland. It is approved by the FDA as Supprelin LA for the treatment of central precocious puberty in children and as Vantas for palliative treatment of advanced prostate cancer in adults.

Vantasis the brand name

Supprelin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Vantas

Histrelin

2004

Effectiveness

How Supprelin Affects PatientsHistrelin is a hormone-regulating drug used to treat central precocious puberty (CPP) in children. It works by blocking the hormone-producing receptors in the pituitary gland, which in turn reduces the production of luteinizing and follicle-stimulating hormones. This slows down the growth velocity, allowing the child to potentially reach their predicted adult height. Histrelin also causes a temporary increase in sex hormone production in the body. When using Histrelin, laboratory tests should be conducted to monitor hormone levels. For CPP, this includes LH, follicle-stimulating hormone and est

How Supprelin works in the bodyHistrelin is a drug that blocks the body's hormones responsible for sexual maturation and reproductive function. When used as an implant, it delivers a continuous dose of the drug. Histrelin acts as a GnRH agonist, which binds to the GnRH receptor and activates it. This causes an increase in circulating levels of LH and FSH hormones. However, over time, the continuous administration of histrelin desensitizes the GnRH receptor and lowers LH and FSH levels. In children with central precocious puberty, this lowers the level of sex steroids and reduces height potential. In adults with prostate cancer, it lowers

When to interrupt dosage

The dosage of Supprelin is contingent upon the determined affliction. The quantity of dosage fluctuates as per the technique of delivery (e.g. Implant; Kit or Implant; Kit - Subcutaneous) featured in the table beneath.

Condition

Dosage

Administration

Prostatic Neoplasms

50.0 mg,

, Subcutaneous, Implant, Implant - Subcutaneous, Implant; Kit, Implant; Kit - Subcutaneous

Puberty, Precocious

50.0 mg,

, Subcutaneous, Implant, Implant - Subcutaneous, Implant; Kit, Implant; Kit - Subcutaneous

Warnings

Supprelin has one contraindication and must not be employed for the conditions compiled in the following table.Supprelin Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Supprelin.

Common Supprelin Drug Interactions

Drug Name

Risk Level

Description

Capromab pendetide

Major

Histrelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.

Corifollitropin alfa

Major

The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Histrelin.

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Histrelin is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Histrelin is combined with Mobocertinib.

Ziprasidone

Major

The risk or severity of QTc prolongation can be increased when Histrelin is combined with Ziprasidone.

Supprelin Toxicity & Overdose RiskTests on animals have shown that histrelin acetate is safe up to 200 mcg/kg for rats and rabbits, and 2000 mcg/kg for mice. This is much higher than the recommended human dose of 10 mcg/kg/day. Studies of patients who received one, two, or four implants of histrelin had similar side effects. There have been no reported cases of overdose in clinical trials of histrelin products, and accidental or intentional overdose is unlikely due to the constant dose delivered by the implants.

Supprelin Novel Uses: Which Conditions Have a Clinical Trial Featuring Supprelin?

At present, four active studies are evaluating the potential of Supprelin in mitigating Advanced Prostate Cancer.

Condition

Clinical Trials

Trial Phases

Prostatic Neoplasms

0 Actively Recruiting

Puberty, Precocious

1 Actively Recruiting

Phase 3

Patient Q&A Section about supprelin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does supprelin last?

"SUPPRELIN® LA needs to be replaced every 12 months."

Answered by AI

What does Supprelin LA treat?

"SUPPRELIN LA is a medication that is implanted under the skin and releases gonadotropin-releasing hormone (GnRH). It is used to treat children who have precocious puberty, a condition in which sexual maturity begins too early."

Answered by AI

How long does histrelin implant last?

"A single histrelin implant is effective in treating central precocious puberty for 2 years, according to a new study. The study was funded by the National Institutes of Health and was published in the New England Journal of Medicine. histrelin is a synthetic hormone that is similar to gonadotropin-releasing hormone.

A single histrelin implant is effective in treating central precocious puberty for 2 years, according to a new study that was funded by the National Institutes of Health and published in the New England Journal of Medicine. Histrelin is a synthetic hormone that is similar to gonadotropin-releasing hormone."

Answered by AI

What does the supprelin implant do?

"An implantable medication, Supprelin LA (histrelin acetate) is used to prevent further progression of puberty. The implant is inserted under the skin on the inside of the upper arm and slowly releases medication into the tissues. This medication is used in cases of precocious puberty or gender dysphoria."

Answered by AI