Tessalon

Acute Bronchitis
Treatment
1 FDA approval
7 Active Studies for Tessalon

What is Tessalon

BenzonatateThe Generic name of this drug
Treatment SummaryBenzonatate is a medication used to suppress cough in patients over 10 years old. It works by desensitizing the tissues in the lungs and pleura that trigger the cough reflex. Benzonatate was approved by the FDA in 1958 and is the only non-narcotic antitussive available by prescription. It has an anesthetic effect similar to drugs like procaine and tetracaine, which can cause severe toxicity and overdose if taken in large enough doses, particularly in children.
Tessalonis the brand name
image of different drug pills on a surface
Tessalon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tessalon
Benzonatate
1958
337

Approved as Treatment by the FDA

Benzonatate, also known as Tessalon, is approved by the FDA for 1 uses including Acute Bronchitis .
Acute Bronchitis

Effectiveness

How Tessalon Affects PatientsBenzonatate is a drug used to reduce coughing caused by both short and long-term respiratory issues. It works by numbing the nerves in the lungs that are responsible for coughing. Studies have shown that it can decrease the number of coughs experienced, and its effects usually kick in after 15-20 minutes and last for 3-8 hours. Benzonatate does not affect the respiratory system in recommended doses.
How Tessalon works in the bodyBenzonatate is a local anesthetic that numbs nerve fibers in the respiratory system. These nerve fibers send signals to the brain when the lungs and airways are stretched, which in turn triggers a cough. By numbing these nerve fibers, benzonatate works to block this signal and stop coughing. It also works by blocking voltage-gated sodium channels in the body.

When to interrupt dosage

The measure of Tessalon is contingent upon the determined condition. The extent of dosage can be found in the table beneath, reliant upon the administration approach (e.g. Tablet or Capsule, liquid filled).
Condition
Dosage
Administration
Acute Bronchitis
100.0 mg, , 200.0 mg, 150.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral

Warnings

Tessalon Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Benzonatate may interact with Pulse Frequency
There are 13 known major drug interactions with Tessalon.
Common Tessalon Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
The serum concentration of Aclidinium can be increased when it is combined with Benzonatate.
Butyrylthiocholine
Minor
The serum concentration of Butyrylthiocholine can be increased when it is combined with Benzonatate.
Chloroprocaine
Minor
The serum concentration of Chloroprocaine can be increased when it is combined with Benzonatate.
Clevidipine
Minor
The serum concentration of Clevidipine can be increased when it is combined with Benzonatate.
Cocaine
Minor
The serum concentration of Cocaine can be increased when it is combined with Benzonatate.
Tessalon Toxicity & Overdose RiskThe toxic dose of benzonatate from taking it orally is 51mg/kg. Symptoms of an overdose usually start within 15-20 minutes and can affect the nervous and cardiovascular systems. In children, swallowing just one or two capsules can be fatal. Signs of overdose include restlessness, tremors, convulsions, coma, swelling in the brain, and cardiac arrest. It is important to empty the stomach and give activated charcoal to help reduce the effects of poisoning. For those with severe poisoning, breathing and kidney support may be needed. In some cases, intravenous fat emulsion therapy may be used to help with life-threatening
image of a doctor in a lab doing drug, clinical research

Tessalon Novel Uses: Which Conditions Have a Clinical Trial Featuring Tessalon?

8 active investigations are being conducted to assess the potential of Tessalon in treating Acute Bronchitis.
Condition
Clinical Trials
Trial Phases
Acute Bronchitis
7 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Early Phase 1

Tessalon Reviews: What are patients saying about Tessalon?

5Patient Review
7/30/2021
Tessalon for Cough
I had a cough for three days that got so bad I couldn't sleep. This medication stopped my coughing within 20 minutes and allowed me to get a good night's rest.
5Patient Review
3/27/2021
Tessalon for Cough
I am three months post-covid and have been having such intense coughing fits that I was getting nosebleeds. Just one day into this treatment, though, and I'm already feeling better.
5Patient Review
10/11/2021
Tessalon for Cough
This medication was a godsend. I had such severe coughing fits from COVID-19 that I genuinely thought I was going to die.
5Patient Review
9/6/2021
Tessalon for Cough
Tessalon perles have been a game-changer for me when it comes to colds and coughs. I can finally get some rest instead of being up all night coughing!
4.7Patient Review
8/18/2022
Tessalon for Cough
My first time using this medication was for a cough related to covid-19. It worked very well and I didn't have to use any cough syrup. Some people it doesn't work for, but that just means it's not the right medication for them.
4.7Patient Review
12/29/2021
Tessalon for Cough
I was desperate to find a way to stop my coughing fits and finally found some relief with this treatment. I would recommend it as a last resort for others in a similar situation.
4.3Patient Review
11/11/2022
Tessalon for Cough
Last night was the first time I took this medication for my covid cough, and it worked wonders! I'll definitely be taking it again. That said, the best cough suppressant I've ever used was hydrocodone syrup when I had whooping cough years ago.
4.3Patient Review
11/22/2020
Tessalon for Cough
I personally didn't see any results, regardless of what others say about this treatment.
3Patient Review
6/2/2022
Tessalon for Cough
I've been prescribed this medication many times, but it has never done anything for me. I know other people who have said how much it helped them, and I wish I could be one of those people.
2.7Patient Review
10/31/2021
Tessalon for Cough
I was diagnosed with a terrible case of pneumonia, and these medication did nothing to help my cough after 4 hours. However, they did give me severe insomnia so instead of sleeping and getting better, I was wide awake. My all natural cough medicine worked much better for me.
2.3Patient Review
2/11/2022
Tessalon for Cough
Over the course of five years, I've been prescribed this medication three times for colds and flu-related coughs. Each time, I saw no difference before or after taking it.
2Patient Review
12/1/2021
Tessalon for Cough
I was disappointed with this medication. I found that it actually made my cough worse, rather than better.
2Patient Review
7/9/2022
Tessalon for Cough
Unfortunately, this treatment did not provide any cough relief for me.
2Patient Review
11/5/2022
Tessalon for Cough
Unfortunately, this medication did not provide any relief for my cough.
1.7Patient Review
8/3/2022
Tessalon for Cough
Ineffective and doctors would rather you suffer than give you a medication that could help. Really disgraceful how the government buts into doctor-patient care.
1.7Patient Review
10/5/2021
Tessalon for Cough
These have never worked for me, unfortunately. I coughed just as much after taking this medication as before. Such a shame that it's prescribed so often when it's ineffective.
1.3Patient Review
11/28/2021
Tessalon for Cough
This did nothing to help my bronchitis. I feel like I wasted my time, and now the doctors are telling me there's nothing they can do. This is the worst feeling, having to rely on over-the-counter treatments again.
1Patient Review
6/7/2021
Tessalon for Cough
I was extremely disappointed with this medication. It not only failed to help my cough, it made it worse.
1Patient Review
11/11/2020
Tessalon for Cough
1Patient Review
8/1/2022
Tessalon for Cough
I took one pill as directed and ended up in the ER a few hours later. I felt incredibly anxious and like I couldn't breathe. The nurse told me to get rid of the rest of them.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tessalon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Tessalon a narcotic?

"Benzonatate is a non-narcotic cough medicine that numbs the throat and lungs, making the cough reflex less active."

Answered by AI

What is Tessalon used for?

"This medication reduces the reflex in the lungs that causes the urge to cough in order to treat coughs caused by the common cold and other breathing problems (such as pneumonia, bronchitis, emphysema, asthma)."

Answered by AI

Will Tessalon make me sleepy?

"If you experience any of the following side effects, you should discontinue use of the medication and seek medical help: severe drowsiness or dizziness, confusion, hallucinations."

Answered by AI

Is tessalon Perles the same as mucinex?

"Mucinex is a brand name for guaifenesin, which is an expectorant. It thins mucus, making it easier to cough up. Benzonatate is an antitussive that suppresses or quiets a cough. Brand names for Benzonatate include Tessalon."

Answered by AI

Clinical Trials for Tessalon

Image of University of California San Diego in San Deigo, United States.

Omeprazole + Lifestyle Therapy for Laryngopharyngeal Reflux

18 - 89
All Sexes
San Deigo, CA
The goal of this clinical trial is to learn if a mechanism guided strategy that utilizes a multidisciplinary approach to treat adults patients (age 18-89) with chronic throat symptoms who are undergoing clinical evaluation for laryngopharyngeal reflux (LPR) is more effective than the usual care strategy with proton pump inhibitor (PPI) therapy used in gastroenterology for these patients. The main question it aims to answer is: Will a greater proportion of the mechanism guided strategy participants achieve symptom response in comparison to the usual care strategy participants? If there is a comparison group: Researchers will compare the mechanism guided strategy to usual care strategy to see if treatment response differs between the groups. Participants will be be asked to do the following: * participate in an 8-week blinded study phase where they will be randomized to either 1) Mechanism Guided Strategy or 2) Usual Care Strategy * take an oral capsule daily (omeprazole 40mg or placebo) * come to 3 in-person visits at UC San Diego Health for an intervention visit with a study provider * consider incorporating recommended lifestyle modifications * complete weekly surveys
Phase 4
Recruiting
University of California San DiegoRena Yadlapati, MD
Image of Medical University of South Carolina in Charleston, United States.

Steroid Injection for Chronic Cough

18+
All Sexes
Charleston, SC
The primary goal of this study is to test the hypothesis that injecting steroid intramuscularly is an effective treatment for unexplained chronic cough. This will be achieved through the design of a prospective, placebo-controlled, single-blind, randomized clinical trial in which one group of patients will undergo a steroid injection into the deltoid muscle and the second group will undergo a placebo injection into the deltoid muscle. Data to determine if a clinically significant difference exists between the outcomes of the two groups will be measured by a dichotomous yes/no response to improvement, the Leicester Cough Questionnaire, and a visual analogue scale for symptom severity. This will provide the answer to the general question of whether or not the intramuscular injections are clinically effective for patients with unexplained chronic cough. Furthermore, any adverse reactions will be thoroughly documented. If this hypothesized treatment is proven effective, this can greatly improve the care of chronic cough patients by allowing for an evidence-based treatment option and a treatment option that may improve access to care. While the superior laryngeal nerve (SLN) injection is typically performed by fellowship trained laryngologists, intramuscular injections could be more widely utilized by general otolaryngologists or providers in other fields of medicine.
Phase < 1
Recruiting
Medical University of South CarolinaLauren Howser
Have you considered Tessalon clinical trials? We made a collection of clinical trials featuring Tessalon, we think they might fit your search criteria.Go to Trials
Image of Kingston Health Sciences Centre in Kingston, Canada.

EVH + Mannitol for Cough Variant Asthma

18 - 65
All Sexes
Kingston, Canada
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough. We hypothesize: 1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls. 2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).
Phase 4
Recruiting
Kingston Health Sciences CentreM. Diane Lougheed, MD, MSc
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security