Trial Summary
What is the purpose of this trial?The purpose of this study is to look for low levels of oxygen (hypoxia) in your cervix cancer using a special x-ray test called a positron emission tomography (PET)scan. Hypoxia may have an effect on how cervix cancer grows and responds to treatments like radiotherapy and chemotherapy. Doctors at Princess Margaret Hospital have measured hypoxia in over 300 patients. The use of PET scans to measure hypoxia may be better and simpler than the methods used previously.
Eligibility Criteria
This trial is for adults with cervical cancer (squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma) who plan to undergo radiotherapy and possibly chemotherapy. They should not have had previous cancer treatment and must be able to lie down for PET scans. Pregnant women are excluded.Inclusion Criteria
My cancer is in stages 1 to 4, may have spread to nearby lymph nodes, and might or might not have spread to distant parts of the body.
I plan to undergo radiotherapy, possibly with cisplatin, for my condition as per PMH Gynecology Group's advice.
I can sign and understand the consent form for this study.
+4 more
Exclusion Criteria
I have had a complete or partial hysterectomy.
I have cancer in the remaining part of my cervix after surgery.
I cannot lie on my back for more than 30 minutes.
+1 more
Participant Groups
The study tests a special x-ray test called a PET scan using 18F-Fluoroazomycin Arabinoside (18F-FAZA) to detect low oxygen levels in cervical cancer tissue, which may affect the tumor's growth and treatment response.
1Treatment groups
Experimental Treatment
Group I: PET FAZA imagingExperimental Treatment1 Intervention
PET FAZA imaging of tumor hypoxia in patients with cervix cancer
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Princess Margaret HospitalToronto, Canada
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Who Is Running the Clinical Trial?
University Health Network, TorontoLead Sponsor