EVH + Mannitol for Cough Variant Asthma

Recruiting in Palo Alto (17 mi)

Overseen byM. Diane Lougheed, MD, MSc

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Recruiting

Sponsor: Dr. Diane Lougheed

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough. We hypothesize: 1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls. 2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).

Eligibility Criteria

This trial is for adults aged 18-65 with cough variant asthma or chronic cough due to methacholine-induced cough but normal airway sensitivity. It's also open to healthy individuals without a history of asthma or chronic cough. People can't join if they've had a recent exacerbation, can't do proper lung function tests, have conditions that make the methacholine test unsafe, or have smoked heavily.

Inclusion Criteria

I have had a chronic cough for over 8 weeks and it improved with asthma treatment.

I am between 18 and 65 years old and have had a stroke or cough caused by methacholine with normal airway sensitivity.

I have had a cough for over 8 weeks and passed a specific breathing test.

+1 more

Exclusion Criteria

I cannot perform a lung function test properly.

I've had a health issue in the last month that required changing my medication or a hospital visit.

You have medical reasons that make it unsafe for you to do the methacholine challenge test.

+1 more

Participant Groups

The study aims to understand how people with certain types of coughs and healthy controls respond to two different stimuli: breathing exercises (EVH) and Mannitol inhalation. Researchers want to see if these cause symptoms like shortness of breath and whether there are differences in lung mechanics between groups.

3Treatment groups

Experimental Treatment

Group I: Methacholine-induced coughExperimental Treatment3 Interventions

Individuals with chronic cough and negative methacholine challenge

Group II: Cough Variant AsthmaExperimental Treatment3 Interventions

Individuals diagnosed with Cough variant asthma

Group III: ControlExperimental Treatment3 Interventions

Individuals with no history of asthma or chronic cough