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What is Tolbutamide
TolbutamideThe Generic name of this drug
Treatment SummaryTolbutamide is a pill used to treat non-insulin-dependent diabetes. It belongs to a class of drugs called sulfonylureas, which work by stimulating the pancreas to release more insulin. This increases the amount of glucose taken up by cells in the body and decreases the amount of glucose made by the liver. Sulfonylureas can cause weight gain, and may cause low blood sugar levels (hypoglycemia), especially in elderly, debilitated, and malnourished individuals. The drug is metabolized in the liver and then excreted in the urine and feces.
Tolbutamideis the brand name
Tolbutamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tolbutamide
Tolbutamide
1979
2
Approved as Treatment by the FDA
Tolbutamide, also called Tolbutamide, is approved by the FDA for 1 uses which include Type 2 Diabetes .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Effectiveness
How Tolbutamide Affects PatientsTolbutamide is a diabetes medicine used in combination with a healthy diet to help lower blood sugar levels in people with type 2 diabetes. It is more powerful than the related second-generation drug glipizide. Tolbutamide works by helping the pancreas release more insulin and helping the body use the insulin better. In order for this drug to be effective, the pancreas must be able to produce insulin.
How Tolbutamide works in the bodySulfonylureas lower blood sugar in people with type 2 diabetes by encouraging the pancreas to release insulin. They do this by attaching to a receptor on the beta cells of the pancreas and blocking certain potassium channels. This causes an influx of calcium and other molecules, leading to the release of insulin-containing granules out of the cell, similar to the effect of glucose.
When to interrupt dosage
The recommended dosage of Tolbutamide is dependent upon the recognized condition. The quantity of dosage fluctuates, in accordance with the administration technique featured in the table beneath.Condition
Dosage
Administration
Type 2 Diabetes
500.0 mg, , 1000.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Tolbutamide ContraindicationsCondition
Risk Level
Notes
Diabetic Ketoacidosis
Do Not Combine
Diabetes Mellitus, Type 1
Do Not Combine
Common Tolbutamide Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Tolbutamide.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Tolbutamide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Tolbutamide.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Tolbutamide.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Tolbutamide.
Tolbutamide Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 2600mg/kg.
Tolbutamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Tolbutamide?
162 active clinical trials are in progress to explore the potential of Tolbutamide in treating Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
168 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Tolbutamide Reviews: What are patients saying about Tolbutamide?
1Patient Review
6/12/2014Patient Q&A Section about tolbutamide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the mechanism of action of tolbutamide?
"Tolbutamide works by stimulating the pancreas to secrete insulin, and by helping the body to use insulin efficiently. The pancreas must be able to produce insulin for this drug to be effective."
Answered by AI
What is the generic name of tolbutamide?
"Orinase (tolbutamide) is a medication used to treat type 2 diabetes. The recommended dose is 500 mg two or three times daily. Possible side effects include low blood sugar, nausea, and headache."
Answered by AI
What is tolbutamide used for?
"Tolbutamide is used to treat high blood sugar levels caused by type 2 diabetes mellitus. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream."
Answered by AI
What are the side effects of tolbutamide?
"The following are symptoms of the disease: nausea, feeling full in the upper abdomen, heartburn, rash, headache, and changes in taste."
Answered by AI