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Diuretic
Chlorthalidone for High Blood Pressure in Older Adults
Phase < 1
Waitlist Available
Led By TAKURO WASHIO, Ph.D.
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 2 weeks post intervention
Summary
This trial aims to study the effects of drug treatment for high blood pressure on brain health in older adults. The researchers will recruit participants with high blood pressure and give them either the drug treatment or a placebo
Who is the study for?
This trial is for older adults with high blood pressure who have not yet started treatment. Participants should be generally healthy, without conditions that could interfere with the study or pose additional risks.
What is being tested?
The study tests if chlorthalidone (a drug for high blood pressure) affects brain blood flow and cognitive function compared to a placebo over two weeks. Researchers will monitor changes in participants' brain health and nervous system regulation.
What are the potential side effects?
Potential side effects of chlorthalidone may include dizziness, dehydration, electrolyte imbalance, and possible impact on kidney function. Placebo has no active ingredients but can cause perceived side effects due to the 'placebo effect.'
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 2 weeks post intervention
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 2 weeks post intervention
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in Cerebral blood flow from baseline at 2 weeks post intervention
Change in Muscle sympathetic nerve activity (MSNA) from baseline at 2 weeks post intervention
Change in cognitive performance from baseline at 2 weeks post intervention via NIH Toolbox Cognitive Battery
+1 moreTrial Design
2Treatment groups
Active Control
Placebo Group
Group I: Antihypertensive drug treatment ArmActive Control1 Intervention
Participants will take a fixed dose of chlorthalidone (a diuretic, 25 mg orally once daily) for two week, with study visits for laboratory assessment at before and after intervention.
Group II: Placebo treatment ArmPlacebo Group1 Intervention
Participants will receive placebo treatment for two weeks, with study visits for laboratory assessment at before and after intervention.
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Who is running the clinical trial?
University of Texas Southwestern Medical CenterLead Sponsor
1,086 Previous Clinical Trials
1,058,612 Total Patients Enrolled
TAKURO WASHIO, Ph.D.Principal InvestigatorUT Southwestern Medical Center