Aspirin for Sleep Deprivation-Related Inflammation

Overseen By Jennifer Scott-Sutherland, M.S.

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: Beth Israel Deaconess Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial is testing if a small amount of aspirin can reduce inflammation caused by irregular sleep patterns in healthy adults. The study focuses on people who restrict sleep for several days and then catch up later. Aspirin helps the body produce substances that turn off inflammation, which might be disrupted by these sleep patterns.

Research Team

Monika Haack, PhD

Principal Investigator

Beth Israel Deaconess Medical Center

Eligibility Criteria

Adults aged 18-65 with a regular sleep pattern of 7-9 hours, starting around 11:00pm, and no significant pre-menstrual discomfort can join. They must not have asthma, high blood pressure, gastrointestinal issues, stroke history, NSAID allergies or intolerance, certain sleep disorders, be pregnant/nursing or taking specific supplements. A clean toxicology screen and BMI between 18.5-35 are required.

Inclusion Criteria

I am between 18 and 65 years old.

Body mass index (BMI) between 18.5 and 35 kg/m2

For female participants: No significant discomfort during pre-menses/menses

Exclusion Criteria

I take medications regularly, but not oral contraceptives.

I haven't taken fish oil or similar supplements in the last 3 months.

I haven't taken NSAIDs or cold/cough medicine in the last month.

Treatment Details

Interventions

• Aspirin (Non-Specific Anti-inflammatory Agent)
• Placebo (Behavioural Intervention)

Trial Overview The trial is testing if aspirin can help manage inflammation caused by disrupted sleep patterns like those from restricted weeknight sleep with weekend catch-up. Participants will either receive aspirin or a placebo to see if it affects inflammatory resolution pathways after such irregular sleep.

Participant Groups

Group I: Sleep Restriction/Non-Active Placebo Experimental Treatment 1 Intervention

Daily intake of pill at bedtime over 2-week period prior to and during the 11-day in-hospital stay

Group II: Sleep Restriction/81mg Aspirin Pill Experimental Treatment 1 Intervention

Daily intake of pill at bedtime over 2-week period prior to and during the 11-day in-hospital stay

Group III: Control Sleep/Non-Active Placebo or 81mg Aspirin Pill Experimental Treatment 2 Interventions

Daily intake of pill at bedtime over 2-week period prior to and during the 11-day in-hospital stay

Who Is Running the Clinical Trial?

Beth Israel Deaconess Medical Center

Lead Sponsor

Trials

872

Recruited

12,930,000+