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Tetracycline Antibiotic

Doxycycline for Rosacea

Phase < 1

Waitlist Available

Led By Raja Sivamani, MD, MS

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1-5 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial studies how antibiotics change lipid molecules and the microbiome in people with rosacea. It aims to find new ways to treat rosacea by understanding these changes, potentially reducing the need for antibiotics.

Eligible Conditions

Eye Redness
Rosacea

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1-5 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1-5 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-5 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Lipidome Change in Diversity

Lipidome Change in Quantity

Microbiome Change in Diversity

+1 more

Side effects data

From 2022 Phase 4 trial • 449 Patients • NCT04050540

Malaria

100%

80%

60%

40%

20%

Study treatment Arm

Standard of Care Arm

dPEP Intervention Arm

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Ocular Rosacea SubjectsExperimental Treatment1 Intervention

Ocular rosacea subjects will receive mandatory Doxycycline intervention and will have samples collected at two visits, before starting intervention and at the completion of the intervention.

Group II: Cutaneous Rosacea SubjectsExperimental Treatment1 Intervention

Doxycycline intervention is optional for cutaneous rosacea subjects. If they do not participate, samples will only be collected at one visit after Dove soap washout. If they do decide to participate, samples will also be collected after completion of the Doxycycline intervention.

Group III: Healthy SubjectsActive Control1 Intervention

Healthy subjects will receive no intervention and will have samples collected only at one visit after Dove soap washout.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Doxycycline

2008

Completed Phase 4

~2650

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