Hypoxia Imaging Techniques for Soft Tissue Sarcoma

Palo Alto (17 mi)

Age: < 65

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: The Hospital for Sick Children

Stay on your current meds

No Placebo Group

Trial Summary

What is the purpose of this trial?This study will test the feasibility of using novel/existing imaging technologies focused on hypoxia measurements to determine "response to therapy" in pediatric soft tissue sarcomas as a pilot study. Specifically, the investigators will compare the sensitivity of Blood Oxygen Level Dependent \[BOLD\], Diffusion-Weighted \[DW\] MRI and Magnetic Resonance Spectroscopy (MRS) with that of conventional MRI to detect measurement changes between the start and completion of neoadjuvant therapy ("response to therapy") in children and adolescents (6-18 years) with suspicion of sarcoma tumors. Clinicians and scientists may use results of the proposed hypoxia-imaging surrogate markers to adjust/modify therapeutic schemes to patients on a personalized basis.

Eligibility Criteria

This trial is for children and adolescents aged 7-18 with suspected or confirmed sarcoma tumors who are candidates for standard chemotherapy, possibly with radiation. It's not suitable for those with other diagnoses, MRI contraindications like metal implants, no need for neoadjuvant therapy, immunodeficiency diseases, another cancer type, or chronic lung disease.

Inclusion Criteria

I am eligible for initial treatment with chemotherapy, possibly including radiation.

I have been diagnosed or suspected to have a sarcoma tumor with a part growing outside the bone.

Exclusion Criteria

I have a long-term lung condition.

I have an immune system disorder, sickle cell, collagen disease, or another cancer.

I am not recommended to have treatment before surgery.

Treatment Details

The study tests imaging technologies to measure tumor hypoxia in pediatric soft tissue sarcomas. It compares BOLD MRI, DW MRI, MRS and 18F-FAZA PET-MRI against conventional MRI to assess response to therapy before surgery.

1Treatment groups

Experimental Treatment

Group I: BOLD- DW- MRSExperimental Treatment3 Interventions

Blood Oxygen Level Dependent \[BOLD\], Diffusion-Weighted \[DW\] MRI, MR Spectroscopy \[MRS\]