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Brain Imaging for Post-Heart Attack Inflammation

Phase 1
Waitlist Available
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Admission to UAB Hospital for ST-elevation acute myocardial infarction (AMI) and treatment with percutaneous coronary intervention (PCI) OR Undergoing elective percutaneous coronary intervention (PCI)
21 years of age or older
Must not have
Prior coronary artery bypass grafting
Prior myocardial infarction
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will test if an investigational drug can show brain inflammation after a heart attack. It may help develop new treatments to protect the brain.

Who is the study for?
This trial is for adults over 21 who've had a recent heart attack treated with PCI or are undergoing elective PCI. They must speak English, have at least an 8th-grade education, and be genetically predisposed to brain inflammation after a heart attack. People can't join if they're pregnant, breastfeeding, have serious health issues that could affect participation, history of severe head injury, major depression or dementia.
What is being tested?
The study tests whether PET/MRI scans using the investigational drug [18F]DPA-714 can detect brain inflammation following a heart attack. This research aims to understand how heart disease affects the brain and may lead to new protective treatments.
What are the potential side effects?
[18F]DPA-714-PET/MRI side effects aren't detailed here but generally include potential reactions from the imaging agent like mild irritation or allergic response and discomfort from lying still during scanning.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am admitted to UAB Hospital for a severe heart attack and treated with PCI, or I am undergoing elective PCI.
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I am 21 years old or older.
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I speak English and have completed at least 8th grade.
Select...
My genetic test shows I have a specific marker (rs6971) for TSPO ligands.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have had heart bypass surgery in the past.
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I have had a heart attack before.
Select...
I have severe anemia.
Select...
I have been diagnosed with major depression.
Select...
I have been diagnosed with dementia.
Select...
My genetic test shows I have a low affinity for TSPO ligands.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
TPSO-PET measurement of neuroinflammation after acute myocardial infarction

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: undergoing elective percutaneous coronary interventionExperimental Treatment1 Intervention
Group II: Recent Myocardial InfarctionExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,656 Previous Clinical Trials
2,444,369 Total Patients Enrolled

Media Library

[18F]DPA-714-PET/MRI Clinical Trial Eligibility Overview. Trial Name: NCT03968445 — Phase 1
Heart Attack Research Study Groups: undergoing elective percutaneous coronary intervention, Recent Myocardial Infarction
Heart Attack Clinical Trial 2023: [18F]DPA-714-PET/MRI Highlights & Side Effects. Trial Name: NCT03968445 — Phase 1
[18F]DPA-714-PET/MRI 2023 Treatment Timeline for Medical Study. Trial Name: NCT03968445 — Phase 1
~3 spots leftby Oct 2028
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