CTX110 for B-Cell Cancers

Recruiting at32 trial locations

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: CRISPR Therapeutics AG

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial tests CTX110, a treatment using modified immune cells from healthy donors, on patients with B-cell cancers that have not responded to other treatments. The immune cells are altered in a lab to better attack cancer cells using gene-editing technology.

Research Team

Annie Weaver, PhD

Principal Investigator

CRISPR Therapeutics

Eligibility Criteria

This trial is for adults with B-cell malignancies like non-Hodgkin's lymphoma or acute lymphoblastic leukemia that didn't respond to at least two prior treatments. Participants must be in good physical condition, have well-functioning major organs, and not be pregnant or breastfeeding. They should agree to use contraception and join a follow-up study.

Inclusion Criteria

My kidney, liver, heart, and lung functions are all good.

I am 18 years old or older with non-Hodgkin lymphoma.

I am between 18 and 70 years old with B cell ALL.

Exclusion Criteria

I have had cancer before, but it was either skin cancer treated by surgery, cervical in situ carcinoma, or any cancer in remission for 5+ years.

I do not have an ongoing serious infection requiring IV drugs.

I have had a stem cell transplant from a donor for my lymphoma.

Treatment Details

Interventions

• CTX110 (CAR T-cell Therapy)

Trial Overview The CARBON trial is testing the safety and effectiveness of CTX110, a new therapy for people with certain blood cancers that have come back or haven't responded to treatment. It's an early-phase study where everyone gets the same experimental treatment.

Participant Groups

Group I: CTX110 Experimental Treatment 1 Intervention

Administered by IV infusion following lymphodepleting chemotherapy.

Who Is Running the Clinical Trial?

CRISPR Therapeutics AG

Lead Sponsor

Trials

9

Recruited

640+