Cannabis for Cigarette Smoking

Palo Alto (17 mi)

Overseen byDustin Lee, PhD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: Johns Hopkins University

No Placebo Group

Approved in 3 jurisdictions

Trial Summary

What is the purpose of this trial?The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.

Eligibility Criteria

This trial is for individuals who regularly use tobacco and cannabis. Participants should be willing to smoke or vape THC in a lab setting. The study excludes those with certain health conditions, but specific exclusion criteria are not listed.

Inclusion Criteria

I smoke tobacco cigarettes every day.

Exclusion Criteria

I have a history of serious heart rhythm problems or vasospastic disease.

Treatment Details

The study examines the effects of different doses of THC (5mg, 30mg, and a placebo with no THC) on cigarette smokers' behavior, cravings, mood changes, heart rate, blood pressure, lung function via breath carbon monoxide levels and thinking skills.

2Treatment groups

Experimental Treatment

Group I: Vaporized THCExperimental Treatment5 Interventions

Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive combustible cigarettes containing 0.03mg and 0.80mg of nicotine.

Group II: Smoked THCExperimental Treatment5 Interventions

Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive combustible cigarettes containing 0.03mg and 0.80mg of nicotine.

THC is already approved in United States, Canada, European Union for the following indications:

🇺🇸 Approved in United States as Dronabinol for: