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Cannabinoid

Cannabis for Cigarette Smoking

Phase 1

Waitlist Available

Led By Dustin Lee, PhD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Report daily use of combustible tobacco cigarettes

Be older than 18 years old

Must not have

Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration.

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to see how taking THC affects people who smoke cigarettes. Researchers will test things like how much people crave cigarettes, their mood, heart rate, blood pressure, and cognitive abilities. They will

Who is the study for?

This trial is for individuals who regularly use tobacco and cannabis. Participants should be willing to smoke or vape THC in a lab setting. The study excludes those with certain health conditions, but specific exclusion criteria are not listed.

What is being tested?

The study examines the effects of different doses of THC (5mg, 30mg, and a placebo with no THC) on cigarette smokers' behavior, cravings, mood changes, heart rate, blood pressure, lung function via breath carbon monoxide levels and thinking skills.

What are the potential side effects?

Possible side effects from THC may include altered mental state or mood changes (like feeling high), increased heart rate, dry mouth or eyes. Smoking cigarettes can cause coughing or throat irritation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I smoke tobacco cigarettes every day.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have a history of serious heart rhythm problems or vasospastic disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Demand Elasticity

Demand Intensity

Secondary study objectives

Brief Questionnaire of Smoking Urges (QSU - Brief) Factor 1

Brief Questionnaire of Smoking Urges (QSU - Brief) Factor 2

Diastolic Blood Pressure

+5 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Vaporized THCExperimental Treatment5 Interventions

Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive combustible cigarettes containing 0.03mg and 0.80mg of nicotine.

Group II: Smoked THCExperimental Treatment5 Interventions

Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive combustible cigarettes containing 0.03mg and 0.80mg of nicotine.

0 / 2Eligibility criteria met