Cannabis for Vaping

Phase 1

Waitlist Available

Led By Dustin Lee, PhD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Must have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration.

Summary

This trial aims to see how THC affects people who use e-cigarettes. They will test things like cravings, mood, heart rate, blood pressure, and cognitive function. Participants who smoke e-cigarettes and use

Who is the study for?

This trial is for individuals who use e-cigarettes and smoke or vape THC. Participants must be willing to try different doses of THC in a controlled lab setting. Specific eligibility criteria are not provided, but typically include age range, health status, and frequency of cannabis and tobacco use.

What is being tested?

The study examines how various doses of THC (high dose, low dose, no THC) affect the desire for e-cigarettes with full nicotine or placebo nicotine. It measures cravings, mood changes, heart rate, blood pressure, breath carbon monoxide levels, and thinking skills.

What are the potential side effects?

Potential side effects may include altered mental state due to high or low doses of THC; increased heart rate; changes in blood pressure; impact on cognitive performance; and possible increase in craving for tobacco products.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have a history of serious heart rhythm problems or spasms in my blood vessels.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, and 6 hours post thc or placebo administration. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Demand Elasticity

Demand Intensity

Secondary study objectives

Brief Questionnaire of Smoking Urges (QSU - Brief) Factor 1

Brief Questionnaire of Smoking Urges (QSU - Brief) Factor 2

Diastolic Blood Pressure

+5 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Vaporized THCExperimental Treatment5 Interventions

Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive e-cigarette containing 0% and 5.0% nicotine.

Group II: Smoked THCExperimental Treatment5 Interventions

Each participant in this arm will receive 0, 5, and 30mg of THC over the course of six visits. Each participant will also receive e-cigarette containing 0% and 5.0% nicotine.

0 / 1Eligibility criteria met