~34 spots leftby Apr 2026

Caffeine for Labor Management

DJ
AM
Overseen ByAngel Marquez, DO
Age: 18+
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 1
Waitlist Available
Sponsor: The Reading Hospital and Medical Center

Trial Summary

What is the purpose of this trial?

Single blind, randomized control trial to determine benefit of caffeine and sodium benzoate on the second stage of labor

Research Team

DJ

Daniel Jiang, MD

Principal Investigator

Reading Hospital Tower Health

Eligibility Criteria

This trial is for first-time pregnant mothers at term (37 weeks or more), who have a way to receive medications through their veins. It's not suitable for those with certain conditions that aren't listed here.

Inclusion Criteria

Patients receiving prenatal care at Tower Health Obstetrical practices
I am a pregnant woman at or past 37 weeks, aged 18-45, with an IV line.

Exclusion Criteria

Fetal malpresentation
I have a history of serious heart conditions.
Positive drug screen on admission for cocaine or amphetamines
See 3 more

Treatment Details

Interventions

  • Caffeine in the Second Stage of Labor (Other)
Trial OverviewThe study is testing if an injection of caffeine and sodium benzoate can help during the second stage of labor, when the mother pushes out the baby. Participants are randomly given either this injection or a normal saline solution without knowing which one they received.
Participant Groups
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Caffeine and sodium benzoateExperimental Treatment1 Intervention
Patients will received 250 mg IV caffeine and sodium benzoate (125 mg each) dissolved in 500 cc normal saline which will be administered over the course of two hours upon determination the patient is 10 cm in cervical dilation.
Group II: PlaceboPlacebo Group1 Intervention
Patients will received 500 cc normal saline which will be administered over the course of two hours upon determination the patient is 10 cm in cervical dilation.

Find a Clinic Near You

Who Is Running the Clinical Trial?

The Reading Hospital and Medical Center

Lead Sponsor

Trials
14
Recruited
1,500+