STK-012 + Pembrolizumab for Cancer
Trial Summary
The combination of STK-012 and Pembrolizumab is unique because it involves using Pembrolizumab, a PD-1 inhibitor that helps the immune system attack cancer cells, in combination with STK-012, which may enhance this effect. This approach is different from standard treatments as it targets the immune system's interaction with cancer, potentially offering a new way to treat cancers that express PD-L1.
12578Pembrolizumab has been shown to improve survival rates in patients with non-small cell lung cancer and melanoma by helping the immune system attack cancer cells more effectively. It has been approved by the FDA for certain types of lung cancer and melanoma, demonstrating significant improvements in patient outcomes compared to traditional chemotherapy.
12567Pembrolizumab, also known as Keytruda, has been used in cancer treatment and is generally considered safe, but it can cause side effects like fatigue, nausea, and immune-related issues such as thyroid problems and, rarely, type 1 diabetes. While specific safety data for the combination with STK-012 is not provided, pembrolizumab's safety profile is well-documented in various cancers.
23467The trial requires that you stop taking any systemic anti-cancer therapy at least 3 weeks before starting the study treatment. If you are taking small molecule kinase inhibitors, you must stop them within 6 elimination half-lives before the first dose. Other medications are not specified, so it's best to discuss with the trial team.
Eligibility Criteria
This trial is for adults with certain advanced solid tumors who have tried standard treatments without success, can't tolerate them, or chose not to use them. They must provide a tumor tissue sample and if they have brain metastases, these should be treated and stable. People can't join if they've had recent cancer therapy or radiotherapy.Exclusion Criteria
Participant Groups
- Head and neck squamous cell carcinoma (HNSCC) with PD-L1 CPS ≥1
- Melanoma
- Non-small cell lung cancer (NSCLC)
- Urothelial carcinoma
- Colorectal cancer
- Gastric cancer
- Hepatocellular carcinoma
- Renal cell carcinoma
- Cervical cancer
- Endometrial carcinoma
- Head and neck squamous cell carcinoma (HNSCC) with PD-L1 CPS ≥1
- Melanoma
- Non-small cell lung cancer (NSCLC)
- Urothelial carcinoma
- Colorectal cancer
- Gastric cancer
- Hepatocellular carcinoma
- Renal cell carcinoma
- Cervical cancer
- Endometrial carcinoma
- Untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) with PD-L1 CPS ≥1