Nitrofurantoin for Urinary Tract Infection

Recruiting at 1 trial location

Overseen By Meghan Leak

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: University of Texas Southwestern Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

The goal of this clinical trial is to learn if the drug Nitrofurantoin (NF) taken as a daily antibiotic, works to treat cystitis compared to electrofulguration (EF) and Nitrofurantoin (NF) daily antibiotic.

Eligibility Criteria

This trial is for women aged 18-85 with a history of recurrent UTIs, who are likely to stay in the study area and have no major health issues like severe allergies to Nitrofurantoin, pregnancy, psychosis, uncontrolled diabetes, or chronic kidney problems. They should not be on antibiotics at the start or have conditions like neurogenic bladder.

Inclusion Criteria

Likely to stay in the geographic region for the duration of the study

ASA class II or less

I am a woman aged 18-85 with a history of UTIs proven by tests.

Exclusion Criteria

Allergy or resistance to Nitrofurantoin

Pregnancy

I am currently taking antibiotics.

Treatment Details

Interventions

• Electrofulguration (Procedure)
• Nitrofurantoin (Anti-infective)

Trial Overview The study compares daily use of Nitrofurantoin (an antibiotic) alone versus combining it with electrofulguration (a procedure that uses electric current to treat tissue) in treating cystitis in women with frequent urinary tract infections.

Participant Groups

Group I: Nitrofurantoin (NF) daily antibiotic prophylaxis plus electrofulguration (EF) Experimental Treatment 2 Interventions

Group II: Nitrofurantoin (NF) daily antibiotic prophylaxis Active Control 1 Intervention

Nitrofurantoin (NF) daily antibiotic prophylaxis given daily for 6 months.

Who Is Running the Clinical Trial?

University of Texas Southwestern Medical Center

Lead Sponsor

Trials

1,102

Recruited

1,077,000+

University of Texas

Collaborator

Trials

193

Recruited

143,000+

National Institutes of Health (NIH)

Collaborator

Trials

2,896

Recruited

8,053,000+