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Joint Replacement

Partial vs Total Knee Replacement for Osteoarthritis

N/A
Waitlist Available
Led By Kevin Fricka, MD
Research Sponsored by Anderson Orthopaedic Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Knee flexion greater than 90 degrees
Varus deformity less than 20 degrees
Must not have
Inflammatory arthritis
History of septic arthritis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
No Placebo-Only Group

Summary

This trial finds that for patients with medial compartment osteoarthritis, UKA results in better function and less pain than TKA.

Who is the study for?
This trial is for people with severe osteoarthritis in one part of the knee, who can bend their knee well and don't have too much leg curvature. It's not for those who are very overweight or have diabetes that isn't well-controlled, serious kidney or liver disease, a history of drug abuse, inflammatory arthritis, or past infections in the joint.
What is being tested?
The study compares two surgical procedures for knee osteoarthritis: unicompartmental (partial) and total knee replacement. Patients will be randomly assigned to receive one of these surgeries to see which is better at improving outcomes.
What are the potential side effects?
Possible side effects include pain at the surgery site, swelling, infection risk increase after surgery, blood clots in legs or lungs (thromboembolism), stiffness in the knee joint and problems with implant like loosening over time.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can bend my knee more than 90 degrees.
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My leg's inward curve is less than 20 degrees.
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I have arthritis in the inner part of my knee.
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My joint bends less than 10 degrees when I try to straighten it.
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I have severe damage in the inner part of my knee.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have inflammatory arthritis.
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I have had septic arthritis in the past.
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I have a torn or damaged ACL.
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My kidney disease is at stage 3A or more advanced.
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I have had surgery to remove part of my knee cartilage.
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I have a long-term liver condition.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Knee Society Score
Secondary study objectives
Revision

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: UKAActive Control1 Intervention
Medial unicompartmental knee arthroplasty
Group II: TKAActive Control1 Intervention
Total knee arthroplasty

Find a Location

Who is running the clinical trial?

Rush University Medical CenterOTHER
436 Previous Clinical Trials
249,140 Total Patients Enrolled
25 Trials studying Osteoarthritis
3,126 Patients Enrolled for Osteoarthritis
Anderson Orthopaedic Research InstituteLead Sponsor
13 Previous Clinical Trials
1,508 Total Patients Enrolled
8 Trials studying Osteoarthritis
1,038 Patients Enrolled for Osteoarthritis
Kevin Fricka, MDPrincipal InvestigatorAnderson Orthopaedic Institute

Media Library

Total Knee Arthroplasty (Joint Replacement) Clinical Trial Eligibility Overview. Trial Name: NCT03385759 — N/A
Osteoarthritis Research Study Groups: UKA, TKA
Osteoarthritis Clinical Trial 2023: Total Knee Arthroplasty Highlights & Side Effects. Trial Name: NCT03385759 — N/A
Total Knee Arthroplasty (Joint Replacement) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03385759 — N/A
~15 spots leftby Dec 2025
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