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PD-1 Inhibitor

RBN-2397 + Pembrolizumab for Small Cell Lung Cancer

Phase 1 & 2
Waitlist Available
Led By Melissa Johnson, MD
Research Sponsored by Ribon Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (an average of 6 months)
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a new drug, RBN-2397, along with pembrolizumab in patients with advanced lung cancer who have not responded to previous treatments. RBN-2397 helps stop cancer cells from hiding from the immune system, while pembrolizumab helps the immune system attack the cancer.

Eligible Conditions
  • Lung Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (an average of 6 months)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (an average of 6 months) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Determine recommended Phase 2 dose (RP2D) (Phase 1b)
Overall Response Rate (Phase 2)
Secondary study objectives
AUC of RBN-2397
Cmax of RBN-2397
Safety determined by Treatment-Emergent Adverse Events
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: RBN-2397 in combination with pembrolizumabExperimental Treatment1 Intervention
RBN-2397 orally in combination with the fixed approved dose of IV pembrolizumab

Find a Location

Who is running the clinical trial?

Ribon Therapeutics, Inc.Lead Sponsor
2 Previous Clinical Trials
202 Total Patients Enrolled
Melissa Johnson, MDPrincipal InvestigatorTennessee Oncology
6 Previous Clinical Trials
883 Total Patients Enrolled

Media Library

Pembrolizumab (PD-1 Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT05127590 — Phase 1 & 2
Lung Cancer Research Study Groups: RBN-2397 in combination with pembrolizumab
Lung Cancer Clinical Trial 2023: Pembrolizumab Highlights & Side Effects. Trial Name: NCT05127590 — Phase 1 & 2
Pembrolizumab (PD-1 Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05127590 — Phase 1 & 2
~14 spots leftby Nov 2025
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