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A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Chronic Low Back Pain

Phase 2
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 8

Summary

This trial tests a new drug to ease chronic back pain. It's part of a protocol to develop better pain treatments.

Eligible Conditions
  • Chronic Lower Back Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 8 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change From Baseline for Average Pain Intensity as Measured by the Numeric Rating Scale (NRS)
Secondary study objectives
Change From Baseline for Worst Pain Intensity as Measured by NRS
Change From Baseline on the EuroQuality of Life Five Dimensions (5D) Five Level (5L) Questionnaire (EQ-5D-5L) Health State Index (United States Algorithm)
Change From Baseline on the Roland Morris Disability Questionnaire (RMDQ)
+4 more

Side effects data

From 2023 Phase 2 trial • 131 Patients • NCT05620576
6%
Urinary tract infection
5%
Pain in extremity
5%
Headache
3%
Vulvovaginal candidiasis
3%
Neuropathy peripheral
2%
Dizziness
1%
Back pain
1%
Cellulitis
1%
Subcutaneous abscess
1%
Fall
100%
80%
60%
40%
20%
0%
Study treatment Arm
45 mg LY3857210
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3857210Experimental Treatment1 Intervention
Participants received 45 milligrams (mg) of LY3857210 orally once daily for up to 8 weeks.
Group II: PlaceboPlacebo Group1 Intervention
Participants received placebo orally once daily for up to 8 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3857210
2022
Completed Phase 2
~430

Find a Location

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,680 Previous Clinical Trials
3,466,246 Total Patients Enrolled
Study DirectorEli Lilly and Company
1,391 Previous Clinical Trials
428,703 Total Patients Enrolled
~45 spots leftby Jan 2026
Unbiased ResultsWe believe in providing patients with all the options.
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