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Exercise for COVID-19 Recovery

Phase 1 & 2
Recruiting
Led By Leighton Chan, M.D.
Research Sponsored by National Institutes of Health Clinical Center (CC)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 10 weeks, 20 weeks (for cross-over group), every 3 months for 1 year after exercise
Awards & highlights
No Placebo-Only Group

Summary

This trial is looking at whether exercise can help people recover from COVID-19.

Who is the study for?
Adults aged 18-80 who had COVID-19 and are still experiencing symptoms like fatigue or physical limitations can join. They must understand English or Spanish, agree to the study's procedures, and have confirmed past infection with lab tests. People with severe psychiatric issues, certain medical conditions, extreme obesity (BMI > 40), or on conflicting medications cannot participate.
What is being tested?
The trial is testing if a rehabilitation exercise program helps recovery from COVID-19. Participants will do aerobic exercises three times a week for ten weeks and attend educational classes. They'll also be monitored through various health tests including heart and lung function, muscle ultrasounds, walking tests, surveys about their daily activities, smell tests, and mental functioning exams.
What are the potential side effects?
While not explicitly listed in the provided information, potential side effects of participating in an aerobic exercise training program may include muscle soreness, fatigue during initial stages of the regimen due to increased activity levels after a period of illness-related inactivity.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 10 weeks, 20 weeks (for cross-over group), every 3 months for 1 year after exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 10 weeks, 20 weeks (for cross-over group), every 3 months for 1 year after exercise for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
6 minute walk test distance
Secondary study objectives
Free-living physical activity and sleep quality
Patient reported outcomes and quality of life

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Education only (CON)Experimental Treatment2 Interventions
Participants will perform only education for the first 10 weeks, then cross-over to perform exercise in the second 10 weeks
Group II: Aerobic Exercise Training and Education (AET+)Experimental Treatment2 Interventions
Participants will perform both exercise training and education for 10 weeks

Find a Location

Who is running the clinical trial?

National Institutes of Health Clinical Center (CC)Lead Sponsor
389 Previous Clinical Trials
30,879,646 Total Patients Enrolled
Leighton Chan, M.D.Principal InvestigatorNational Institutes of Health Clinical Center (CC)
8 Previous Clinical Trials
599 Total Patients Enrolled

Media Library

Aerobic Exercise Training Clinical Trial Eligibility Overview. Trial Name: NCT04595773 — Phase 1 & 2
Coronavirus Research Study Groups: Education only (CON), Aerobic Exercise Training and Education (AET+)
Coronavirus Clinical Trial 2023: Aerobic Exercise Training Highlights & Side Effects. Trial Name: NCT04595773 — Phase 1 & 2
Aerobic Exercise Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT04595773 — Phase 1 & 2
~18 spots leftby Dec 2025
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