CD30 CAR T-Cells for Testicular Cancer
Trial Summary
What is the purpose of this trial?
This trial tests a new treatment to fight certain types of cancer in adults. The treatment aims to improve how the body targets and kills cancer cells. Researchers will collect samples to see how well the treatment works and lasts in the body.
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the idea that CD30 CAR T-Cells for Testicular Cancer is an effective treatment?
The available research shows that CD30 CAR T-Cells have demonstrated antitumor activity against embryonal carcinomas, a type of testicular cancer, in both laboratory and animal studies. These cells were able to target and kill cancer cells that express the CD30 marker, as well as nearby cancer cells that do not express this marker, through a special interaction. This suggests that CD30 CAR T-Cells could be a promising treatment for testicular cancer, especially for aggressive types that are difficult to treat with standard therapies.12345
What safety data is available for CD30 CAR T-Cell therapy in testicular cancer?
The safety data for CD30 CAR T-Cell therapy, while not specific to testicular cancer, can be inferred from general CAR T-Cell studies. CAR T-Cell therapies, including those targeting CD30, have shown potential in treating hematologic malignancies with some success. However, they are associated with risks such as cytokine release syndrome, neurotoxicity, and 'on-target off-tumor' effects, where healthy cells expressing the target antigen may also be affected. Strategies to mitigate these risks, such as pharmacologic interventions and suicide genes, are under investigation. CD30 CAR T-Cells have been noted to spare CD30+ hematopoietic stem cells while targeting lymphoma cells, suggesting a level of safety in targeting CD30. Overall, while promising, CAR T-Cell therapies require careful management of potential toxicities.678910
Is the treatment ATLCAR.CD30 Cells a promising treatment for testicular cancer?
Yes, ATLCAR.CD30 Cells, which are a type of CAR T-cell therapy, show promise for treating testicular cancer. They can target and kill cancer cells that have the CD30 marker, and they can also attack nearby cancer cells that don't have this marker. This makes them a strong candidate for treating aggressive forms of testicular cancer.1451112
Research Team
Matthew Milowsky, MD
Principal Investigator
UNC Lineberger Comprehensive Cancer Center
Eligibility Criteria
Adults over 18 with Nonseminomatous Germ Cell Tumors (NSGCT) who've had at least one prior treatment can join. They must show tumor growth or elevated cancer markers after high-dose chemo. Pregnant women, those breastfeeding, and individuals with active HIV, HTLV, hepatitis B or C are excluded.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Administration of autologous T lymphocyte chimeric antigen receptor cells targeted against the CD30 antigen (ATLCAR.CD30) to subjects with CD30+ Nonseminomatous Germ Cell Tumors
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of overall response rate and progression-free survival
Long-term Follow-up
Monitoring of overall survival and persistence of ATLCAR.CD30 in peripheral blood
Treatment Details
Interventions
- ATLCAR.CD30 Cells (CAR T-cell Therapy)
- Cyclophosphamid (Alkylating agents)
- Fludarabine (Anti-metabolites)
Find a Clinic Near You
Who Is Running the Clinical Trial?
UNC Lineberger Comprehensive Cancer Center
Lead Sponsor
Dr. Shelley Earp
UNC Lineberger Comprehensive Cancer Center
Chief Medical Officer since 2018
MD from Johns Hopkins Medical School
Dr. Robert L. Ferris
UNC Lineberger Comprehensive Cancer Center
Chief Executive Officer
PhD in Immunology and MD from Johns Hopkins Medical School; Bachelor's in Chemistry from UNC-Chapel Hill
University Cancer Research Fund at Lineberger Comprehensive Cancer Center
Collaborator