Oral Minoxidil for Platinum-Resistant Ovarian Cancer

Recruiting in Palo Alto (17 mi)

Overseen byMargaret Liotta, DO

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Recruiting

Sponsor: Loyola University

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial is testing if minoxidil, a blood pressure medication, can help treat ovarian cancer that doesn't respond to standard treatments. It works by changing the cell's internal environment to stop cancer growth. The study aims to see if it can reduce tumor size with fewer side effects.

Eligibility Criteria

This trial is for adults over 18 with recurrent platinum-resistant ovarian cancer, who can take pills and have an ECOG Performance Status of 2 or less. They must not have had chemo or radiotherapy in the last 4 weeks, be on other trials, have heart failure or disease, be on dialysis, have brain metastases, allergies to minoxidil, or uncontrolled high blood pressure.

Inclusion Criteria

My cancer came back within 6 months after platinum-based treatment.

My ovarian cancer has come back and does not respond to platinum-based treatments.

I can take care of myself and am up and about more than half of my waking hours.

+2 more

Exclusion Criteria

Participants must not be receiving any other investigational agents.

You cannot have had allergic reactions to minoxidil.

I do not have congestive heart failure.

+5 more

Participant Groups

The study tests if oral Minoxidil helps patients with recurrent platinum-resistant ovarian cancer. It looks at how many respond to treatment, time before the disease gets worse again and records any side effects. It also explores whether a genetic factor (Kir6/SUR complex) affects Minoxidil's effectiveness.

1Treatment groups

Experimental Treatment

Group I: TreatmentExperimental Treatment1 Intervention

Participants in this arm will be treated with minoxidil. This treatment will be given daily by mouth.