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Vasodilator
Oral Minoxidil for Platinum-Resistant Ovarian Cancer
Phase 2
Recruiting
Led By Margaret Liotta, DO
Research Sponsored by Loyola University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Participants must have platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment.
Participants must have an Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2.
Must not have
Participants must not have congestive heart failure
Participants must not have brain metastases
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 24 months
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing if minoxidil, a blood pressure medication, can help treat ovarian cancer that doesn't respond to standard treatments. It works by changing the cell's internal environment to stop cancer growth. The study aims to see if it can reduce tumor size with fewer side effects.
Who is the study for?
This trial is for adults over 18 with recurrent platinum-resistant ovarian cancer, who can take pills and have an ECOG Performance Status of 2 or less. They must not have had chemo or radiotherapy in the last 4 weeks, be on other trials, have heart failure or disease, be on dialysis, have brain metastases, allergies to minoxidil, or uncontrolled high blood pressure.
What is being tested?
The study tests if oral Minoxidil helps patients with recurrent platinum-resistant ovarian cancer. It looks at how many respond to treatment, time before the disease gets worse again and records any side effects. It also explores whether a genetic factor (Kir6/SUR complex) affects Minoxidil's effectiveness.
What are the potential side effects?
Minoxidil may cause side effects such as fluid retention leading to rapid weight gain; swelling of face, hands, ankles; difficulty breathing; fast heartbeat; nausea; vomiting; breast pain/tenderness; changes in hair growth/loss.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My cancer came back within 6 months after platinum-based treatment.
Select...
I can take care of myself and am up and about more than half of my waking hours.
Select...
I am 18 years old or older.
Select...
I can take medicine by mouth.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I do not have congestive heart failure.
Select...
I do not have cancer that has spread to my brain.
Select...
My blood pressure is under control.
Select...
I have no history of heart disease.
Select...
I am not on dialysis.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 24 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Overall response rate (ORR)
Secondary study objectives
Progression-free survival (PFS)
Side effects data
From 2015 Phase 2 trial • 21 Patients • NCT0087620056%
Hypertrichosis
11%
Strabismus correction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Minoxidil
Placebo
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
Participants in this arm will be treated with minoxidil. This treatment will be given daily by mouth.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Minoxidil
2011
Completed Phase 2
~170
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for ovarian cancer include chemotherapy agents such as paclitaxel, which stabilizes microtubules and inhibits cell division, and topotecan, which inhibits topoisomerase I, leading to DNA damage and cell death. Pegylated liposomal doxorubicin intercalates DNA and inhibits topoisomerase II, causing apoptosis.
Targeted therapies like bevacizumab inhibit vascular endothelial growth factor (VEGF), reducing tumor blood supply. Minoxidil, a potassium channel opener and vasodilator, is being studied for its potential to disrupt cancer cell proliferation by altering cellular ion balance and improving drug delivery through enhanced blood flow.
Understanding these mechanisms is crucial for tailoring treatments to improve efficacy and manage resistance in ovarian cancer patients.
Find a Location
Who is running the clinical trial?
Loyola UniversityLead Sponsor
160 Previous Clinical Trials
31,422 Total Patients Enrolled
4 Trials studying Ovarian Cancer
76 Patients Enrolled for Ovarian Cancer
Cures Within ReachOTHER
23 Previous Clinical Trials
2,125 Total Patients Enrolled
Medical University of South CarolinaOTHER
979 Previous Clinical Trials
7,400,960 Total Patients Enrolled
1 Trials studying Ovarian Cancer
150 Patients Enrolled for Ovarian Cancer
Margaret Liotta, DOPrincipal InvestigatorLoyola University
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My cancer came back within 6 months after platinum-based treatment.You cannot have had allergic reactions to minoxidil.I do not have congestive heart failure.My ovarian cancer has come back and does not respond to platinum-based treatments.I can take care of myself and am up and about more than half of my waking hours.I do not have cancer that has spread to my brain.I haven't had chemotherapy or radiotherapy in the last 4 weeks.My blood pressure is under control.I have no history of heart disease.I am not on dialysis.I am 18 years old or older.I can take medicine by mouth.
Research Study Groups:
This trial has the following groups:- Group 1: Treatment
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.