Tadalafil for Fontan Physiology
Trial Summary
If you are currently using intravenous inotropic drugs, alpha-blockers, pulmonary vasodilators, or nitrates, you will need to stop taking them to participate in this trial.
Research shows that Tadalafil significantly improves heart function, exercise performance, and quality of life in patients who have undergone the Fontan procedure, which is a heart surgery for certain congenital heart defects.
12345Tadalafil is generally safe for humans, with most side effects being mild or moderate and often disappearing without stopping the medication. It does not increase the risk of heart problems and can be safely used with blood pressure medications.
13678Tadalafil is unique in its use for Fontan physiology as it specifically targets myocardial and endothelial function, improving heart function and exercise performance, which is not the primary focus of other treatments like Sildenafil that mainly reduce pulmonary artery pressure and increase oxygen saturation.
135910Eligibility Criteria
Adults over 18 who've had a Fontan Palliation, can exercise on a supine bike, and are able to have an MRI. They must be willing to give written consent and be scheduled for cardiac catheterization. It's not for those under 18, pregnant or breastfeeding women, people on certain heart medications, or unable to exercise.Inclusion Criteria
Exclusion Criteria
Participant Groups
- Erectile dysfunction
- Pulmonary hypertension
- Erectile dysfunction
- Pulmonary hypertension