CBD for Chronic Pain

Phase 2

Recruiting

Led By Kevin Boehnke, PhD

Research Sponsored by Kevin Boehnke

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Reports moderate to severe chronic pain defined by protocol

Be older than 18 years old

Must not have

Current diagnosis of cancer

Having a serious or unstable hepatic disease (e.g., non-alcoholic fatty liver disease or liver cirrhosis)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up days 1-28

Summary

This trial is looking at the effects of CBD, which comes from marijuana, on chronic pain in Veterans. The goal is to see if CBD can help improve pain symptoms in Veterans with chronic pain. Participants

Who is the study for?

This trial is for Veterans experiencing chronic pain. Participants will be randomly assigned to receive either a placebo or CBD, which is an active component of cannabis thought to help with pain.

What is being tested?

The study aims to determine if CBD can provide better relief from chronic pain symptoms in Veterans compared to a placebo (a substance with no therapeutic effect).

What are the potential side effects?

While the trial's description doesn't specify side effects, common ones associated with CBD may include tiredness, diarrhea, and changes in appetite or weight.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I experience chronic pain that is moderate to severe.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am currently diagnosed with cancer.

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I do not have serious liver conditions like cirrhosis.

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I am currently taking valproate and clobazam.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ days 1-28

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~days 1-28

This trial's timeline: 3 weeks for screening, Varies for treatment, and days 1-28 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Global impression of change (PGIC) between groups at end of treatment (Day 28)

Secondary study objectives

Anxiety based on the Patient Reported Outcomes Measurement Information System (PROMIS)-29+2 Profile v2.1

Change in pain interference based on the pain interference 4a short form items from the Patient Reported Outcomes Measurement Information System (PROMIS)-29+2 Profile v2.1

Change in suicidal ideation based on Positive and Negative Suicide Ideation (PANSI) Inventory

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