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Lithium for Parkinson's Disease

Phase 1 & 2
Waitlist Available
Led By Thomas Guttuso, MD
Research Sponsored by State University of New York at Buffalo
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial will look at how 24 weeks of lithium treatment with specific blood levels affects MRI and blood markers in Parkinson's disease patients who have already finished a previous lithium trial.

Who is the study for?
This trial is for Parkinson's disease patients who have already completed a 24-week lithium clinical trial. It aims to further investigate the effects of lithium therapy on certain biomarkers.
What is being tested?
The study tests the impact of a 24-week course of lithium aspartate, aiming for specific low serum levels, on MRI and blood-based markers in Parkinson's patients.
What are the potential side effects?
While not explicitly listed here, common side effects from lithium may include tremors, increased thirst and urination, nausea or diarrhea, weight gain, and cognitive issues.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Free Water
Serum neurofilament light chain
Secondary study objectives
Fatigue Severity Scale
Geriatric Depression Scale-15
Insomnia Severity Index
+8 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Lithium aspartateExperimental Treatment1 Intervention
Lithium aspartate with dosage adjusted to achieve a serum lithium level of 0.25-0.50mmol/L

Find a Location

Who is running the clinical trial?

State University of New York at BuffaloLead Sponsor
268 Previous Clinical Trials
52,295 Total Patients Enrolled
Thomas Guttuso, MDPrincipal InvestigatorUniversity at Buffalo
1 Previous Clinical Trials
15 Total Patients Enrolled
~23 spots leftby Feb 2026
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