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Novel Antineuronal Antibodies in Gastrointestinal Motility Disorders

N/A
Waitlist Available
Led By Pankaj J Pasricha, MD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights
No Placebo-Only Group

Summary

Gastrointestinal motility disorders represent a heterogeneous group of neuromuscular diseases of the enteric nervous systems. While autoimmune neuromuscular diseases of the central nervous system (CNS) are well described, the role of autoimmunity in enteric nervous system (ENS) has been less studied. Approximately 10% of patients with unexplained gastrointestinal dysmotility diseases have positive serum autoantibodies to peripheral nervous system proteins, suggesting an autoimmune mechanism targeting the enteric nervous system. The investigator's aim is to identify novel anti neuronal antibodies that contribute to autoimmune gastrointestinal motility disorders by analyzing the serum of patients with abnormal gastrointestinal motility.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Antibodies for Autoimmune Gastrointestinal Dysmotility

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Antibody isolation, DNA isolationExperimental Treatment1 Intervention
Patients with GI dysmotility
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Blood sample collection
2014
Completed Phase 4
~16190

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,339 Previous Clinical Trials
14,881,331 Total Patients Enrolled
Pankaj J Pasricha, MDPrincipal InvestigatorJohns Hopkins University
8 Previous Clinical Trials
1,109 Total Patients Enrolled
Ken J Hui, MDPrincipal InvestigatorJohns Hopkins University
~59 spots leftby Dec 2025
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