Proton Beam Therapy for Chondrosarcoma
Recruiting in Palo Alto (17 mi)
+1 other location
Age: Any Age
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: M.D. Anderson Cancer Center
No Placebo Group
Prior Safety Data
Approved in 4 Jurisdictions
Trial Summary
What is the purpose of this trial?
The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. The safety of this treatment will also be studied.
Research Team
DG
David R. Grosshans
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for individuals with a type of bone cancer called chondrosarcoma located at the base of the skull. Participants should have had most of their tumor surgically removed, be able to perform daily activities with minimal assistance (Karnofsky Performance status ≥60), and must provide signed consent. They cannot join if they have cancer spread throughout the body or previous radiation treatment to the skull base.Inclusion Criteria
I've had a detailed brain scan at M. D. Anderson within the last 3 months.
I've had surgery to remove as much of my skull base tumor as possible.
My cancer is a Grade 1-3 chondrosarcoma located at the base of my skull.
See 2 more
Exclusion Criteria
I have had radiation treatment on the base of my skull.
My cancer has spread to other parts of my body.
Treatment Details
Interventions
- Proton Beam Therapy (Proton Beam Therapy)
Trial OverviewThe study is examining how effective proton beam therapy is on its own or combined with photon beam radiation in treating skull base chondrosarcoma. Researchers want to see how well these therapies work and monitor their safety for patients.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Proton Beam TherapyExperimental Treatment1 Intervention
Proton Beam Therapy - A total dose of up to 70 CGE given at 2.0 CGE per daily fraction for 35 fractions.
Proton Beam Therapy is already approved in Japan, Canada for the following indications:
Approved in Japan as Proton Beam Therapy for:
- Various cancers including prostate, liver, and ocular melanoma
Approved in Canada as Proton Therapy for:
- Various cancers including ocular melanoma and certain pediatric cancers
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
Trials
3,107
Recruited
1,813,000+
Dr. Peter WT Pisters
M.D. Anderson Cancer Center
Chief Executive Officer since 2017
MD from University of Western Ontario
Dr. Jeffrey E. Lee
M.D. Anderson Cancer Center
Chief Medical Officer
MD from Stanford University School of Medicine