← Back to Search

Vaccine Therapy for Blood Cancers

Phase 2
Waitlist Available
Led By Ryotaro Nakamura, MD
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 100 days after transplant

Summary

This trial looks at how well a vaccine can reduce the number of cytomegalovirus infections in people with blood cancer who are getting a stem cell transplant from a donor.

Who is the study for?
This trial is for patients with blood cancers like lymphoma, leukemia, and myelodysplastic syndrome who are undergoing stem cell transplants. They must understand the study, agree to follow-up procedures for a year post-transplant, be HLA A*0201 positive, CMV seropositive, not pregnant or breastfeeding, willing to use contraception and have no recent experimental anti-CMV treatments.
What is being tested?
The trial tests if a vaccine made from a peptide can reduce severe cytomegalovirus infections in patients after donor stem cell transplant. It's randomized: some get the actual vaccine while others receive a placebo. The goal is to see how well the immune system responds.
What are the potential side effects?
While specific side effects aren't listed here, vaccines may cause reactions at the injection site (like pain or swelling), feverish feelings or chills shortly after administration. More serious side effects could include allergic reactions or affecting other parts of the immune system.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 100 days after transplant
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 100 days after transplant for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cumulative Incidence of CMV at 100 Days
Secondary study objectives
Cumulative Incidence of Relapse at One Year
Non-Relapse Mortality (NRM) at 100 Days

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm I (CMVpp65-A*0201 peptide vaccine)Experimental Treatment2 Interventions
Patients receive CMVpp65-A\*0201 peptide vaccine SC on days 28 and 56 after HCT.
Group II: Arm II (placebo)Placebo Group2 Interventions
Patients receive placebo SC on days 28 and 56 after HCT.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CMVpp65-A*0201 peptide vaccine
1997
Completed Phase 1
~50

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,924 Previous Clinical Trials
41,017,890 Total Patients Enrolled
2 Trials studying Blood Cancers
112 Patients Enrolled for Blood Cancers
City of Hope Medical CenterLead Sponsor
602 Previous Clinical Trials
1,923,519 Total Patients Enrolled
Ryotaro Nakamura, MDPrincipal InvestigatorCity of Hope Medical Center
5 Previous Clinical Trials
175 Total Patients Enrolled

Media Library

CMVpp65-A*0201 peptide vaccine Clinical Trial Eligibility Overview. Trial Name: NCT02396134 — Phase 2
Blood Cancers Research Study Groups: Arm II (placebo), Arm I (CMVpp65-A*0201 peptide vaccine)
Blood Cancers Clinical Trial 2023: CMVpp65-A*0201 peptide vaccine Highlights & Side Effects. Trial Name: NCT02396134 — Phase 2
CMVpp65-A*0201 peptide vaccine 2023 Treatment Timeline for Medical Study. Trial Name: NCT02396134 — Phase 2
~6 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top