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Preventative Skin Care for Pediatric Brain Cancer

Phase 2

Waitlist Available

Led By Jennifer Huang, MD

Research Sponsored by Dana-Farber Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo treatment with at least one of the following: Targeted BRAF inhibitor therapy, Targeted MEK inhibitor therapy, Targeted pan-RAF inhibitor therapy

Be younger than 65 years old

Must not have

Diagnosed with brain tumor at > 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial tests a skin care routine for children with brain tumors undergoing cancer treatments. The routine includes gentle skin care, sun protection, and bleach baths. It aims to reduce skin problems caused by the treatments.

Who is the study for?

This trial is for children aged 6 months to 18 years with a brain tumor, who will be treated with specific targeted therapies (BRAF, MEK, or pan-RAF inhibitors). They must be able to follow a skin care routine including sun protection and bleach baths. Children with allergies to sunscreen or skincare products used in the study cannot participate.

What is being tested?

The study tests whether a preventive skin care regimen can help children undergoing treatment for brain tumors with certain inhibitors. The regimen includes dilute bleach baths, high SPF sunscreen, moisturizers, protective clothing, and limited sun exposure.

What are the potential side effects?

Potential side effects may include skin irritation from the bleach baths or allergic reactions to the skincare products like sunscreen and moisturizers. Sunscreen might also cause discomfort if there's an existing sensitivity.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I was diagnosed with a brain tumor as a child and will be treated with targeted therapy.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I was diagnosed with a brain tumor as an adult.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Rate of Cutaneous Reaction

Secondary study objectives

Children's Dermatology Quality of life

Hand foot syndrome Severity

Overall Cutaneous Reaction Severity

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Preventative Skin Care RoutineExperimental Treatment6 Interventions

Participants will perform a preventative skin care routine that includes daily sun protection, daily gentle skin care and every-other-day dilute bleach baths for the duration of the study. Participants will receive skin examinations and complete a survey about their skin condition at the initial visit when anti-cancer treatment is started, at six weeks after the start of treatment, and at twelve weeks after the start of treatment.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Dana-Farber Cancer InstituteLead Sponsor

1,110 Previous Clinical Trials

358,278 Total Patients Enrolled

Jennifer Huang, MD3.04 ReviewsPrincipal Investigator - Boston Children's Hospital

Dana-Farber Cancer Institute

2 Previous Clinical Trials

12 Total Patients Enrolled

1Patient Review

Will give you a severe diagnosis to scare you, make you wait 3 months for an appointment, and then just tell you bug bites. Made my wife feel unintelligent for not being a native English speaker.