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N/A

Dextromethorphan for Musculoskeletal Disease

Phase 2
Waitlist Available
Led By Jarred W Younger, PhD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 20 weeks
Awards & highlights
All Individual Drugs Already Approved

Summary

This trial is testing if DXM, a common cough medicine ingredient, can reduce pain in people with Fibromyalgia by calming brain inflammation. If successful, it could offer a new way to manage this chronic condition.

Eligible Conditions
  • Musculoskeletal Disease
  • Fibromyalgia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~20 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Daily Self-reported Pain Severity
Secondary study objectives
Daily Self-reported Physical Activity
Patient Global Impression of Change

Side effects data

From 2013 Phase 4 trial • 45 Patients • NCT01766050
14%
Headache
100%
80%
60%
40%
20%
0%
Study treatment Arm
Inje Cocktail Alone and Inje Cocktail Plus Belatacept

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: DextromethorphanExperimental Treatment1 Intervention
Participant will take one dextromethorphan 10mg capsule in the morning and at night.
Group II: PlaceboPlacebo Group1 Intervention
Participants will take one placebo capsule in the morning and at night.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dextromethorphan
FDA approved

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,646 Previous Clinical Trials
2,342,746 Total Patients Enrolled
Jarred W Younger, PhDPrincipal InvestigatorUniversity of Alabama at Birmingham
1 Previous Clinical Trials
39 Total Patients Enrolled
~4 spots leftby Nov 2025
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