Proton Therapy for Recurrent Head and Neck Cancer

Recruiting in Palo Alto (17 mi)

+11 other locations

Overseen by Nancy Lee, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate the tumor control and the side effects of using proton therapy for head and neck cancer that has come back.

Research Team

Nancy Lee, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

This trial is for adults over 18 with recurrent or new primary head and neck cancer, previously treated with radiation. It's not suitable for pregnant women, those unable to follow the study procedures, or patients who finished prior radiation less than 6 months ago.

Inclusion Criteria

I am willing and able to sign a consent form.

I am 18 years old or older.

I have received radiation treatment to my head or neck area.

Exclusion Criteria

I am not pregnant or breastfeeding.

It's been less than 6 months since my last radiation therapy.

Inability to comply with study and/or follow-up procedures

Treatment Details

Interventions

• Conventionally Fractionated Full Dose Re-irradiation (Radiation)
• Hypofractionated Palliative Re-irradiation (Radiation)
• Proton Therapy (Proton Beam Therapy)

Trial Overview The study tests proton therapy as a treatment for recurring head and neck cancer. Patients will receive either full dose re-irradiation if they have more than 6 months life expectancy or palliative care if less.

Participant Groups

Group I: hypofractionated palliative re-irradiation Experimental Treatment 1 Intervention

Group II: fractionated full dose re-irradiation Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials

1,998

Recruited

602,000+

Lisa M. DeAngelis

Memorial Sloan Kettering Cancer Center

Chief Medical Officer since 2021

MD from Columbia University

Selwyn M. Vickers

Memorial Sloan Kettering Cancer Center

Chief Executive Officer since 2022

MD from Johns Hopkins University