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Calcium Channel Blocker
Medical Therapy for Myocardial Bridging
Phase 2
Waitlist Available
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Summary
This trial tests beta blockers and calcium channel blockers on adults with chest pain and myocardial bridges but no blocked arteries. These medications may help by relaxing heart muscles and improving blood flow, potentially reducing chest pain. Beta blockers and calcium channel blockers have been shown to be effective in treating angina pectoris, often used in combination to enhance therapeutic effects.
Eligible Conditions
- Myocardial Bridging
- Coronary artery bridge
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Effectiveness of beta blockers and calcium channel blockers for reducing angina in patients with a Myocardial Bridge (MB) compared to placebo
Secondary study objectives
Changes in exercise capacity.
Other study objectives
Drug adherence.
Side effects.
Trial Design
3Treatment groups
Active Control
Placebo Group
Group I: Beta Blocker (nebivolol)Active Control1 Intervention
Group II: Calcium Channel Blocker (diltiazem)Active Control1 Intervention
Group III: PlaceboPlacebo Group1 Intervention
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Who is running the clinical trial?
Stanford UniversityLead Sponsor
2,484 Previous Clinical Trials
17,515,761 Total Patients Enrolled
1 Trials studying Myocardial Bridging
150 Patients Enrolled for Myocardial Bridging
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- Your heart has a lower than normal pumping ability.You had a very bad reaction to beta blockers or calcium channel blockers in the past.Your blood pressure is lower than 100 over 0 or your heart beats slower than 50 times per minute when you are resting.You are 18 years old or older.You have stable chest pain that fits specific criteria.You do not want to take beta blockers or calcium channel blockers.You have recently experienced a serious heart condition like unstable angina, heart attack, or cardiogenic shock.You have had a heart transplant in the past.You have another condition that could explain your chest pain, like lung pressure, heart muscle thickening, or narrowed aortic valve.You don't have any symptoms.You do not have blockages in your heart arteries, as shown by specific tests.You are taking a medication that can have a harmful interaction with beta blockers or calcium channel blockers.You have had an exercise stress test in the past six months.You have had a test that shows you have a condition called myocardial bridge.
Research Study Groups:
This trial has the following groups:- Group 1: Beta Blocker (nebivolol)
- Group 2: Calcium Channel Blocker (diltiazem)
- Group 3: Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.