Radiation Therapy for Sarcoma

Recruiting in Palo Alto (17 mi)

Overseen byMatthew J Krasin, MD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: St. Jude Children's Research Hospital

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

Researchers at St. Jude Children's Research Hospital are looking for more effective ways to deliver radiation therapy to pediatric tumors of the bone and soft tissues. The goal of the study is to improve local control of musculoskeletal tumors with image-guided radiation therapy (IGRT) while minimizing radiation related side effects. IGRT uses computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) images to precisely define tumor location and to carefully plan radiation treatment. This approach allows doctors to deliver highly conformal radiation therapy to the tumor while protecting nearby healthy normal tissues.

Research Team

Matthew J Krasin, MD

Principal Investigator

St. Jude Children's Research Hospital

Eligibility Criteria

This trial is for individuals up to 25 years old with musculoskeletal tumors such as sarcoma, who haven't had prior radiation at the tumor site (except for emergency treatment). It includes those with or without metastatic disease and allows patients undergoing various treatments like surgery or chemotherapy. Pregnant women can't participate, and those with recurrent tumors are eligible if the area hasn't been irradiated before.

Inclusion Criteria

Patients enrolled prior to amendment 4.0, who are still in active participation will be reconsented to the current version of the protocol (5.0).

Negative serum or urine beta-HCG for females of child bearing age.

I am 25 years old or younger and enrolling for the first time.

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Treatment Details

Interventions

Image-guided radiotherapy (Radiation Therapy)

Trial OverviewThe study tests image-guided radiotherapy (IGRT) in treating pediatric bone and soft tissue tumors. IGRT uses advanced imaging techniques like CT, MRI, and PET scans to target radiation precisely at the tumor while sparing healthy tissues around it.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: TreatmentExperimental Treatment1 Intervention

Eligible patients will be accessioned at the time of irradiation and undergo a pre-radiotherapy evaluation, treatment planning, image-guided radiotherapy delivery and intra-and post-irradiation evaluations.