LED Therapy for Traumatic Brain Injury

(LED-TBI Trial)

Overseen by Yelena Bogdanova, PhD PhD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: VA Office of Research and Development

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial tests if special lights can help people with brain injuries by making their brain cells work better. It aims to improve memory, sleep, and overall quality of life. Previous research has shown that using these lights after a brain injury can protect brain cells.

Research Team

Yelena Bogdanova, PhD PhD

Principal Investigator

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Eligibility Criteria

This trial is for English-speaking adults aged 21-55 who have experienced a mild traumatic brain injury (TBI) with loss of consciousness for no more than 30 minutes. It's specifically aimed at active-duty personnel or veterans exposed to blasts. People with penetrating head injuries, previous neurological or psychotic disorders, or significant hearing or vision impairments cannot participate.

Inclusion Criteria

LOC of 30 min or less

Veterans who have had a traumatic brain injury or exposure to blasts during their service in Iraq or Afghanistan.

I am between 21 and 55 years old.

Exclusion Criteria

I have a history of neurological conditions.

You had a mental illness like schizophrenia before a head injury.

I have difficulty with my hearing or vision.

Treatment Details

Interventions

• LED (Other)
• sham LED (Other)

Trial Overview The study is testing the effectiveness of light emitting diodes (LED) therapy compared to a fake LED treatment (sham) in improving cognitive function and quality of life for those with TBI. Participants will be randomly assigned to receive either the real LED treatment or sham.

Participant Groups

Group I: Active LED Experimental Treatment 1 Intervention

Active LED Treatment

Group II: Sham LED Placebo Group 1 Intervention

Inactive (sham) LED Treatment

Who Is Running the Clinical Trial?

VA Office of Research and Development

Lead Sponsor

Trials

1,691

Recruited

3,759,000+

Dr. Grant Huang

VA Office of Research and Development

Acting Chief Research and Development Officer

PhD in Medical Psychology and Master of Public Health from the Uniformed Services University of Health Sciences

Dr. Erica M. Scavella

VA Office of Research and Development

Chief Medical Officer since 2022

MD from University of Massachusetts School of Medicine