Brimonidine for Oculofacial Surgery

Overseen by Christopher Compton, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University of Louisville

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

This trial tests if brimonidine eye drops can help control bleeding in patients having eye-related plastic surgery by making blood vessels smaller. Brimonidine has been studied for its effectiveness in reducing bleeding and improving visibility during various eye surgeries, including trabeculectomy, LASIK, and strabismus surgery.

Research Team

Christopher Compton, MD

Principal Investigator

University of Louisville

Eligibility Criteria

This trial is for adults over 18 needing oculoplastic surgery due to conditions like droopy eyelids. It's not suitable for those with eye infections, a history of CNS depression from meds, clotting issues, current brimonidine use, certain asymmetrical eye conditions, very low eye pressure (hypotony), known brimonidine allergy or side effects, a history of low blood pressure (hypotension), orthostatic hypotension, or if pregnant.

Inclusion Criteria

I am older than 18 years.

I need eye surgery due to a condition.

Exclusion Criteria

Pregnancy

I have experienced brain fog or drowsiness from medication.

I experience significant drops in blood pressure when standing up.

Treatment Details

Interventions

• Brimonidine Topical (Alpha-2 Adrenergic Agonist)

Trial Overview The study is testing the effectiveness of a topical medication called Brimonidine in controlling bleeding during facial surgeries involving the eyes. The goal is to see how well it works when applied directly to the surgical area.

Participant Groups

Group I: Brimonidine intervention Experimental Treatment 1 Intervention

We will compare hemostasis between 2 surgical sides of the same patient. One side will be randomized to receive Brimonidine (0.15% or 0.2%) in addition to standard hemostasis measures, while the other side will receive only standard hemostasis measures (preoperative discontinuation of blood thinners, preoperative injection of lidocaine with epinephrine).

Group II: Control Arm Active Control 1 Intervention

We will compare hemostasis between 2 surgical sides of the same patient. One side will be randomized to receive Brimonidine (0.15% or 0.2%) in addition to standard hemostasis measures, while the other side will receive only standard hemostasis measures (preoperative discontinuation of blood thinners, preoperative injection of lidocaine with epinephrine).

Who Is Running the Clinical Trial?

University of Louisville

Lead Sponsor

Trials

353

Recruited

76,400+