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CYP2D6 rapid metabolizer for Postoperative Nausea

Phase 4
Waitlist Available
Led By Yvette N Martin, MD, PhD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0-48 hours post bariatric surgery
Awards & highlights

Summary

The Researchers overall goal is to evaluate the benefit and utility of preemptive genotypic data to guide post-operative nausea and vomiting treatment in the bariatric surgical population. The hypothesis is that using genotypic variation in CYP2D6 to select the appropriate 5HT3 serotonin receptor antagonist to treat PONV will decrease rates of PONV in the bariatric surgical population.

Eligible Conditions
  • Postoperative Nausea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0-48 hours post bariatric surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-48 hours post bariatric surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Episodes of Postoperative Nausea
Episodes of Postoperative Vomiting

Trial Design

2Treatment groups
Experimental Treatment
Group I: CYP2D6 rapid metabolizerExperimental Treatment1 Intervention
Participants with CYP2D6 rapid metabolizer status will received granisetron for for post operative nausea and vomiting prophylaxis and treatment
Group II: CYP2D6 normal metabolizerExperimental Treatment1 Intervention
Participants with CYP2D6 poor or normal metabolizer status will received 4mg ondansetron for post operative nausea and vomiting prophylaxis and treatment
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Granisetron
FDA approved
Ondansetron
FDA approved

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,307 Previous Clinical Trials
2,962,307 Total Patients Enrolled
Yvette N Martin, MD, PhDPrincipal InvestigatorMayo Clinic
~13 spots leftby Sep 2025
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