Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery

Recruiting at 1 trial location

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Tarek M. El-Achkar

Approved in 7 Jurisdictions

Trial Summary

What is the purpose of this trial?

This study proposes to investigate whether treatment with minocycline pre-operatively in patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce the occurence of kidney injury.

Research Team

Tarek M El-Achkar, MD

Principal Investigator

St. Louis University

Eligibility Criteria

Inclusion Criteria

Age over 18 years

planned CABG or valvular surgery with cardiopulmonary bypass

Serum creatinine available (within 30 days)

Treatment Details

Interventions

• Minocycline (Tetracycline Antibiotic)

Participant Groups

Group I: minocycline Active Control 1 Intervention

Group II: placebo Placebo Group 1 Intervention

Minocycline is already approved in Japan, India for the following indications:

Approved in Japan as Minopen for:

• Bacterial infections

Approved in India as Minoz for:

• Bacterial infections

Who Is Running the Clinical Trial?

Tarek M. El-Achkar

Lead Sponsor

Trials

1

Recruited

40+

Satellite Healthcare

Collaborator

Trials

27

Recruited

5,900+

Triax Pharmaceuticals

Collaborator

Trials

1

Recruited

40+