← Back to Search

Other

Transcranial Magnetic Stimulation for Alcoholism

N/A

Waitlist Available

Led By Brett C Ginsburg, PhD

Research Sponsored by The University of Texas Health Science Center at San Antonio

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Able to attend all study appointments

Be older than 18 years old

Must not have

Females will be excluded if they are pregnant

Psychiatrically or medically unsafe to participate due to a documented diagnostic history of bipolar disorder, schizophrenia or schizoaffective disorder

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 1 month and 6 months

Awards & highlights

No Placebo-Only Group

Summary

"This trial is testing a new treatment called IR-TMS to help people who drink too much alcohol reduce their alcohol intake. Participants will receive different versions of this treatment and undergo sessions, brain scans, and

Who is the study for?

This trial is for individuals struggling with Alcohol Use Disorder (AUD) who are seeking a new treatment option. Participants must be willing to undergo brain scans, provide samples, and answer questions about their drinking habits and mental health.

What is being tested?

The study tests IR-TMS, a non-invasive procedure using magnetic fields to target brain areas linked to addiction. It aims to reduce alcohol cravings by varying the treatment across three groups in multiple sessions alongside regular monitoring through MRI scans and sample collection.

What are the potential side effects?

While the description doesn't list specific side effects, TMS can sometimes cause discomfort at the stimulation site, headache, lightheadedness or seizures in very rare cases. The intensity of these side effects may vary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can attend all required study visits.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am not pregnant.

Select...

I do not have a history of bipolar, schizophrenia, or schizoaffective disorder.

Select...

I have a history of serious medical or neurological conditions, including seizures.

Select...

I have had a brain injury where I was unconscious for 20 minutes or more.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 1 month and 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 1 month and 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1 month and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Measure of Phosphatidylethanol (PEth) level

Secondary study objectives

Brain functional connectivity

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Active Control

Group I: Orbitofrontal cortex (OFC) IR-TMSActive Control1 Intervention

Stimulation will be delivered to either the OFC at a depth corrected intensity of 80-95 V/m, using a theta burst stimulation protocol which delivers 1,800 pulses/session. Sessions will be compressed and delivered up to 4 times per day, over the course of 2 weeks.

Group II: Left dorsolateral prefrontal cortex (L-DLPFC) IR-TMSActive Control1 Intervention

Stimulation will be delivered to the L-DLPFC at a depth corrected intensity of 80-95 V/m, using a theta burst stimulation protocol which delivers 1,800 pulses/session. Sessions will be compressed and delivered up to 4 times per day, over the course of 2 weeks.

Group III: Dorsomedial prefrontal cortex (DMPFC) IR-TMSActive Control1 Intervention

Stimulation will be delivered to either the DMPFC at a depth corrected intensity of 80-95 V/m, using a theta burst stimulation protocol which delivers 1,800 pulses/session. Sessions will be compressed and delivered up to 4 times per day, over the course of 2 weeks.

0 / 5Eligibility criteria met