Transcranial Magnetic Stimulation for Alcoholism

(TMS Trial)

Overseen by Merideth A Addicott, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Wake Forest University Health Sciences

No Placebo Group

Trial Summary

What is the purpose of this trial?

Alcohol use disorder (AUD) is a complex chronic brain disease characterized by compulsive alcohol use, loss of control over drinking, and negative emotional states. Extensive research has identified the general neural circuitry underlying AUD. There is an exciting opportunity to intervene in AUD using neuromodulation. Transcranial magnetic stimulation (TMS) offers a non-invasive method to modulate brain activity, making it a promising tool for investigating, modulating, and potentially treating AUD. However, the precise effects of TMS on neural circuits involved in AUD and the mechanisms underlying these effects must first be understood. Magnetoencephalography (MEG) is a neuroimaging method that provides direct measurement of brain activity within neural circuits with high temporal resolution. Critically, MEG can measure brain activity in a wide range of frequencies that are consistent with those targeted by TMS. The goal of this proposal is therefore to collect preliminary and feasibility data to support a future NIH grant application that would use MEG to investigate TMS effects in individuals with AUD (iAUD).

Research Team

Merideth A Addicott, PhD

Principal Investigator

Wake Forest University Health Sciences

Eligibility Criteria

This trial is for individuals with Alcohol Use Disorder (AUD). To join, participants must have a certain score on the DSM-5 and AUDIT indicating they either consume little to no alcohol or are heavy alcohol consumers. Those who don't meet these specific criteria cannot participate.

Inclusion Criteria

* Diagnostic and Statistical Manual of Mental Disorders (DSM-5) score for AUD = 0

* Alcohol Use Disorders Identification Test (AUDIT) score ≤ 7

* Is not a heavy alcohol consumer

Treatment Details

Interventions

• Transcranial Magnetic Stimulation (TMS) (Behavioural Intervention)

Trial Overview The study tests how Transcranial Magnetic Stimulation (TMS) affects brain activity in people with AUD using Magnetoencephalography (MEG). Different frequencies of TMS, including 10 Hz and 1 Hz, as well as active and sham intermittent Theta Burst Stimulation (iTBS), are being compared.

Participant Groups

Group I: Two Day - Option 2 Experimental Treatment 2 Interventions

Participants will receive sham iTBS then active iTBS.

Group II: Two Day - Option 1 Experimental Treatment 2 Interventions

Participants will receive active iTBS then sham iTBS.

Group III: Four Day - Option 2 Experimental Treatment 4 Interventions

Participants will receive sham iTBS, active iTBS, 1 Hz, 10 Hz.

Group IV: Four Day - Option 1 Experimental Treatment 4 Interventions

Participants will receive active iTBS, sham iTBS, 10 Hz, 1 Hz.

Who Is Running the Clinical Trial?

Wake Forest University Health Sciences

Lead Sponsor

Trials

1,432

Recruited

2,506,000+