Sleep and Exercise for Alzheimer's Disease (CASE Trial)
Recruiting in Palo Alto (17 mi)
+1 other location
Overseen ByAzizi A Seixas, PhD
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: NYU Langone Health
No Placebo Group
Approved in 1 jurisdiction
Trial Summary
What is the purpose of this trial?This trial is studying whether better sleep and more exercise can reduce the risk of dementia in people who are at risk. The idea is that these lifestyle changes might help keep the brain healthy.
Is the treatment Exercise Routine a promising treatment for Alzheimer's Disease?Yes, Exercise Routine is a promising treatment for Alzheimer's Disease. Research shows that exercise can improve sleep quality, which is important because sleep problems are linked to Alzheimer's. Exercise helps people sleep better by affecting body temperature and other body functions. This makes it a valuable non-drug option for improving sleep and potentially reducing Alzheimer's risk.49101214
Do I need to stop my current medications to join the trial?The trial protocol does not specify whether you need to stop taking your current medications.
What safety data exists for exercise and sleep treatments in Alzheimer's?The research indicates that exercise has beneficial effects on Alzheimer's disease, improving functionality, daily life activities, neuropsychiatric disturbances, cardiovascular fitness, and cognitive components. However, specific safety data for the Dreem 2 Headband or Fitbit devices in Alzheimer's treatment is not detailed in the provided studies.15678
What data supports the idea that Sleep and Exercise for Alzheimer's Disease is an effective treatment?The available research shows that exercise can be beneficial for people with Alzheimer's disease. Studies have found that exercise helps improve daily life activities, mental health, heart and lung fitness, and physical abilities like flexibility and balance. It also helps with some mental skills, such as attention and memory. Compared to other treatments, exercise is a non-drug option that can improve both physical and mental health in Alzheimer's patients.2381113
Eligibility Criteria
This trial is for individuals experiencing memory, concentration, or information processing issues who can do mild exercise and wear a DREEM 2 Headband and Fitbit watch. They must be able to handle a digital device and perform the Everlywell biomarker test. Participants should speak English and consent willingly.Inclusion Criteria
I have issues with memory, focusing, or understanding information.
Exclusion Criteria
I cannot use a smartphone or similar technology.
Participant Groups
The study examines how sleep quality and an exercise routine might influence dementia risk over time using tools like the DREEM 2 Headband to monitor sleep patterns and a Fitbit watch to track activity levels.
3Treatment groups
Experimental Treatment
Active Control
Group I: Sleep Only GroupExperimental Treatment1 Intervention
Participants in this group will wear the DREEM 2 headband for 12 weeks.
Group II: Exercise Only GroupActive Control1 Intervention
Participants in this group will workout twice a week for 12 weeks.
Group III: Exercise and Sleep GroupActive Control2 Interventions
Participants in this group will take part in a guided exercise program in additional to wearing the DREEM 2 headband for 12 weeks.
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
University of Miami HospitalsMiami, FL
NYU Langone HealthNew York, NY
Loading ...
Who is running the clinical trial?
NYU Langone HealthLead Sponsor
University of MiamiLead Sponsor
DreemIndustry Sponsor
Shipley FoundationCollaborator
References
Feasibility [corrected] of regular physical exercise for patients with moderate to severe Alzheimer disease. [2019]Physical activity delays loss of autonomy in the elderly. In patients with Alzheimer disease (AD), physical activity could be a useful strategy in therapeutic management by delaying loss of functional independence and the usual complications of the disease.
Benefits of physical exercise for older adults with Alzheimer's disease. [2008]The physical and mental benefits of exercise are widely known but seldom available to persons suffering from Alzheimer's disease (AD). This article presents information on the potential benefits of physical exercise for people with AD, discussing some of the metabolic and neuropathological changes regarded as underlying causes of AD, as well as some of the psychological and organic abnormalities that can be modified through exercise. The extent to which physical exercise programs can play a role in the treatment of AD is addressed in the second part of the article, describing the most relevant clinical studies in this field. Finally, the article provides information about how to prescribe physical exercise for AD patients, mainly by giving examples of structured physical programs designed for older adults with dementia.
Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: the Maximizing Independence in Dementia (MIND) study. [2022]To determine the feasibility and efficacy of a home-based exercise intervention program to improve the functional performance of patients with Alzheimer's Disease (AD).
Impact of physical fitness and daily energy expenditure on sleep efficiency in young and older humans. [2022]Physical activity is known to influence sleep efficiency. Relatively little is known about the relationship between physical activity and sleep efficiency in young and older humans and the impact of exercise training on sleep efficiency in healthy older individuals.
Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients. [2015]To assess the contribution of a multimodal exercise program on the sleep disturbances (SD) and on the performance of instrumental activities daily living (IADL) in patients with clinical diagnosis of Alzheimer's disease (AD) and Parkinson's disease patients (PD).
What are older Latinos told about physical activity and cognition? A content analysis of a top-circulating magazine. [2021]Physical activity (PA) may reduce risk of developing Alzheimer's disease (AD). The objectives of this study were to: (a) Compare the content of English and Spanish PA-focused articles in American Association of Retired Persons (AARP) magazines; and (b) Determine whether these articles discuss PA as a potential correlate of AD.
[Impact of a psychomotor re-education guide on the quality of life of patients with Alzheimer's disease]. [2018]We developed a psychomotor re-education guide (PSEG) adapted to people with Alzheimer disease (AD), including a cognitive stimulation program integrated with the exercise recommendations of the American College of Sports Medicine.
What are the Benefits of Exercise for Alzheimer's Disease? A Systematic Review of the Past 10 Years. [2018]To identify and characterize the scientific literature on the effects of exercise on Alzheimer's disease, research was conducted in the following databases: MEDLINE, CINAHL, Web of Science, and Scopus. These MeSH terms--"exercise", "motor activity", "physical fitness", "Alzheimer disease", and its synonyms in English--were used in the initial search to locate studies published between 2003 and 2013. After reading the 12 final articles in their entirety, two additional articles, found by a manual search, were included. Of these, 13 had beneficial results of exercise in Alzheimer's disease. Given the results discussed here, the exercise may be important for the improvement of functionality and performance of daily life activities, neuropsychiatric disturbances, cardiovascular and cardiorespiratory fitness, functional capacity components (flexibility, agility, balance, strength), and improvements in some cognitive components such as sustained attention, visual memory, and frontal cognitive function in patients with AD.
Effect of exercise and cognitive activity on self-reported sleep quality in community-dwelling older adults with cognitive complaints: a randomized controlled trial. [2022]To compare the effects of different types of physical and mental activity on self-reported sleep quality over 12 weeks in older adults with cognitive and sleep complaints.
Effects of Zero-time Exercise on inactive adults with insomnia disorder: a pilot randomized controlled trial. [2019]To evaluate the feasibility and clinical effects of a lifestyle-integrated exercise, namely zero-time exercise (ZTEx), on improving insomnia in inactive adults with insomnia disorder.
[Effect of physical exercise on Alzheimer's disease. A sistematic review]. [2021]The objective of this review is to analyze through a the scientific evidence about the effects of physical activity in patients with Alzheimer's disease (AD) as a preventive and non-pharmacological treatment.
The effect of resistance training on sleep in Chinese older adults: A randomized controlled trial. [2021]Sleep disturbances affect approximately half of the older adult population and add additional risks of developing Alzheimer's disease. This study is to test the effects of a 12-week resistance training (RT) program on sleep in older adults residing in an assisted living facility in China. A total of 62 eligible participants were randomly assigned to RT (n = 31) or control group (n = 31). Participants in RT group participated in three 1-hour moderate intensity RT sessions per week for 12 weeks (at least 48 h between sessions). In the overall sample, sleep efficiency increased (P
Effectiveness of Physical Exercise on Alzheimer's disease. A Systematic Review. [2022]A systematic review of randomized controlled trials was conducted to determine the effect of physical exercise on physical-functional capacity, cognitive performance, neuropsychiatric symptoms, and quality of life in a population of older people with Alzheimer´s disease.
Sleep disorders and exercise: a mini-review. [2023]Sleep disturbance in a growing problem in the general population. As the prevalence of sleep disturbance rises, interest in treatment modalities including non-pharmaceutical interventions also grows. One of these potential modalities is exercise therapy. In individuals without sleep disorders, exercise appears to be beneficial in improving sleep architecture without any impact of the timing of exercise in relation to onset of sleep. The mechanisms for this are largely unknown but may be due to a combination of the effects of exercise on body temperature, autonomic control, endocrine and metabolic function. In obstructive sleep apnoea (OSA), supervised exercise therapy appears to have positive impact on daytime sleepiness with an unknown impact on sleep quality. The effect of exercise on central sleep apnoea (CSA) will be difficult to ascertain due to the low prevalence of this condition. In primary sleep disorders such as insomnia, narcolepsy and restless syndrome exercise may be useful in improving sleep architecture but the quality of the evidence supporting this remains low. In addition, the timing of exercise in relation to sleep onset remains under investigated. In individuals with circadian rhythm disorders, evening exercise appears to delay sleep onset. In shift-pattern workers, individuals with increased cardiorespiratory fitness report better sleep quality, suggesting exercise may be protective in this important population. To allow high quality evidence-based recommendations to be made about the value of exercise in individuals with sleep disorders, there is a significant need for large prospective studies with objective and subjective sleep quality as a primary outcome.