← Back to Search

Electrical Stimulation

Electrical Stimulation for Learning and Memory in Alzheimer's and Primary Progressive Aphasia

Verified Trial
N/A
Recruiting
Led By Kyrana Tsapkini, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have you had any previous brain injuries (stroke, traumatic brain injury, tumors)?
Are you right-handed?
Timeline
Screening 2 days
Treatment 6 months
Follow Up 0 days
Awards & highlights
No Placebo-Only Group

Summary

This trial tests a new treatment for Alzheimer's patients using a gentle electrical brain stimulation combined with memory exercises. It aims to help those who struggle with memory or language by improving brain cell connections. Transcutaneous electrical nerve stimulation (TENS) has shown positive effects on memory, verbal fluency, and affective behavior in Alzheimer's patients in previous studies.

Who is the study for?
This trial is for right-handed individuals aged 50-75 with a high-school education, proficient in English, and diagnosed with Alzheimer's Disease or Primary Progressive Aphasia. They must have cognitive impairment consistent with AD biomarkers but no history of brain injuries like stroke or tumors.
What is being tested?
The study tests if electrical brain stimulation (HD-tDCS) combined with a Word List Learning Intervention can improve verbal learning in typical and atypical Alzheimer's patients by comparing active treatment to sham (placebo). It also examines changes in brain connectivity and neurotransmitter levels.
What are the potential side effects?
While the document doesn't specify side effects, tDCS is generally considered safe but may cause mild discomfort, itching, tingling on the scalp during application, headache, fatigue or nausea.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have had a previous brain injury.
Select...
I have been diagnosed with Alzheimer's Disease or Primary Progressive Aphasia.

Timeline

Screening ~ 2 days
Treatment ~ 6 months
Follow Up ~0 days
This trial's timeline: 2 days for screening, 6 months for treatment, and 0 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in auditory delayed recall accuracy of semantically related - trained word-lists
Change in auditory delayed recall accuracy of semantically related - untrained word-lists
Change in auditory delayed recall accuracy of semantically unrelated - trained word-lists
+5 more
Secondary study objectives
Change in Gamma-Aminobutyric Acid (GABA) concentration
Change in Mini Mental State Examination (MMSE)
Change in Mnemonic Similarity Task (MST) score
+22 more
Other study objectives
Correlation of primary and with sleep efficiency

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Sham+word intervention then active HD-tDCS+word interventionExperimental Treatment3 Interventions
Participants will receive Sham + Word List Learning Intervention (WordLLI) and then active HD-tDCS + WordLLI after a three-month washout period.
Group II: Active HD-tDCS+word intervention then Sham+word interventionExperimental Treatment3 Interventions
Participants will receive active HD-tDCS + Word List Learning Intervention (WordLLI) and then receive Sham + WordLLI after a three-month washout period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sham
2013
Completed Phase 3
~2090

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Alzheimer's Disease (AD) include cholinesterase inhibitors and neuromodulation techniques such as Transcranial Direct Current Stimulation (tDCS). Cholinesterase inhibitors, like donepezil, rivastigmine, and galantamine, work by increasing cholinergic transmission in the brain, which can provide modest symptomatic relief in cognition and global functioning. tDCS, a non-invasive neuromodulation technique, enhances synaptic activity and functional connectivity in the brain, particularly in areas involved in language and memory. This is significant for AD patients as it may help mitigate cognitive decline and improve verbal learning and memory functions, potentially enhancing their quality of life.
Neurostimulation in Alzheimer's disease: from basic research to clinical applications.2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.

Find a Location

Logistics

Other reimbursement is provided

Other forms of reimbursement are provided for this trial.

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,805 Previous Clinical Trials
28,195,181 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,339 Previous Clinical Trials
14,881,541 Total Patients Enrolled
Kyrana Tsapkini, PhDPrincipal InvestigatorJohns Hopkins University
6 Previous Clinical Trials
420 Total Patients Enrolled

Media Library

Active HD-tDCS (Electrical Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT04122001 — N/A
Alzheimer's Disease Research Study Groups: Active HD-tDCS+word intervention then Sham+word intervention, Sham+word intervention then active HD-tDCS+word intervention
Alzheimer's Disease Clinical Trial 2023: Active HD-tDCS Highlights & Side Effects. Trial Name: NCT04122001 — N/A
Active HD-tDCS (Electrical Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04122001 — N/A
Alzheimer's Disease Patient Testimony for trial: Trial Name: NCT04122001 — N/A
~8 spots leftby May 2025